ArticleProceedings. Biological sciences2015
Correlation between Hox code and vertebral morphology in archosaurs.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Evolution of the reptile spine reveals independent trajectories to axial skeletal complexity in amniotes.Nature communications · 2026Article
- New perspectives on head and neck allometry and ecomorphology in tetrapods.Biological reviews of the Cambridge Philosophical Society · 2026Review
- The Peculiar Necks of Herons and Anhingas: A Study of Cervical Morphology in Pelecanimorph Birds.Integrative organismal biology (Oxford, England) · 2026Article
- Modularity and integration of the neural arch and vertebral centrum in primates.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- A simple model reveals why complex evolutionary innovations follow predictable paths.bioRxiv : the preprint server for biology · 2025Article
- Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars.bioRxiv : the preprint server for biology · 2025Article
- Heterochrony and Oophagy Underlie the Evolution of Giant Filter-Feeding Lamniform Sharks.Evolution & development · 2025Article
- Homeotic and nonhomeotic patterns in the tetrapod vertebral formula.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Extreme neck elongation evolved despite strong developmental constraints in bizarre Triassic reptiles-implications for neck modularity in archosaurs.Royal Society open science · 2024Article
- The neck as a keystone structure in avian macroevolution and mosaicism.BMC biology · 2023Article
- Intravertebral vs. intervertebral integration and modularity in the vertebral column of mammalian carnivorans.Journal of anatomy · 2023Article
- Dinosaurs: Comparative Cytogenomics of Their Reptile Cousins and Avian Descendants.Animals : an open access journal from MDPI · 2022Review
- Regionalization, constraints, and the ancestral ossification patterns in the vertebral column of amniotes.Scientific reports · 2022Article
- Variation in vertebrae shape across small-bodied newts reveals functional and developmental constraints acting upon the trunk region.Journal of anatomy · 2022Article
- Article
- Evolutionary versatility of the avian neck.Proceedings. Biological sciences · 2021Article
- Decelerated dinosaur skull evolution with the origin of birds.PLoS biology · 2020Article
- Development and evolution of the tetrapod skull-neck boundary.Biological reviews of the Cambridge Philosophical Society · 2020Review
- Article
- Vertebral morphometrics and lung structure in non-avian dinosaurs.Royal Society open science · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between developmental genes and phenotypic variation is of central interest in evolutionary biology. An excellent example is the role of Hox genes in the anteroposterior regionalization of the vertebral column in vertebrates. Archosaurs (crocodiles, dinosaurs including birds) are highly variable both in vertebral morphology and number. Nevertheless, functionally equivalent Hox genes are active in the axial skeleton during embryonic development, indicating that the morphological variation across taxa is likely owing to modifications in the pattern of Hox gene expression. By using geometric morphometrics, we demonstrate a correlation between vertebral Hox code and quantifiable vertebral morphology in modern archosaurs, in which the boundaries between morphological subgroups of vertebrae can be linked to anterior Hox gene expression boundaries. Our findings reveal homologous units of cervical vertebrae in modern archosaurs, each with their specific Hox gene pattern, enabling us to trace these homologies in the extinct sauropodomorph dinosaurs, a group with highly variable vertebral counts. Based on the quantifiable vertebral morphology, this allows us to infer the underlying genetic mechanisms in vertebral evolution in fossils, which represents not only an important case study, but will lead to a better understanding of the origin of morphological disparity in recent archosaur vertebral columns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.