ArticleProceedings. Biological sciences2015
Bottlenecks in domestic animal populations can facilitate the emergence of Trypanosoma cruzi, the aetiological agent of Chagas disease.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- One health approach to chagas disease: a systematic review on the integration of human, animal, and environmental health.Frontiers in health services · 2026Pooled it
- The impact of temperature on canine Chagas disease transmission risk: A modeling study.PLoS neglected tropical diseases · 2025Article
- Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics.Biology · 2023Article
- Modeling the impact of xenointoxication in dogs to halt Trypanosoma cruzi transmission.PLoS computational biology · 2023Article
- Modeling the impact of xenointoxication in dogs to haltmedRxiv : the preprint server for health sciences · 2023Article
- A review of neurological health disparities in Peru.Frontiers in public health · 2023Review
- Elucidating the Mechanism ofTropical medicine and infectious disease · 2020Article
- Prevalence, infected density or individual probability of infection? Assessing vector infection risk in the wild transmission of Chagas disease.Proceedings. Biological sciences · 2020Article
- Dispersal patterns of Trypanosoma cruzi in Arequipa, Peru.PLoS neglected tropical diseases · 2020Article
- Virus epidemics, plant-controlled population bottlenecks and the durability of plant resistance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Article
- Toward an Ecological Framework for Assessing Reservoirs of Vector-Borne Pathogens: Wildlife Reservoirs of Trypanosoma cruzi across the Southern United States.ILAR journal · 2017Article
- Heterogeneous infectiousness in guinea pigs experimentally infected with Trypanosoma cruzi.Parasitology international · 2016Article
- Broad patterns in domestic vector-borne Trypanosoma cruzi transmission dynamics: synanthropic animals and vector control.Parasites & vectors · 2015Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
Faeces-mediated transmission of Trypanosoma cruzi (the aetiological agent of Chagas disease) by triatomine insects is extremely inefficient. Still, the parasite emerges frequently, and has infected millions of people and domestic animals. We synthesize here the results of field and laboratory studies of T. cruzi transmission conducted in and around Arequipa, Peru. We document the repeated occurrence of large colonies of triatomine bugs (more than 1000) with very high infection prevalence (more than 85%). By inoculating guinea pigs, an important reservoir of T. cruzi in Peru, and feeding triatomine bugs on them weekly, we demonstrate that, while most animals quickly control parasitaemia, a subset of animals remains highly infectious to vectors for many months. However, we argue that the presence of these persistently infectious hosts is insufficient to explain the observed prevalence of T. cruzi in vector colonies. We posit that seasonal rains, leading to a fluctuation in the price of guinea pig food (alfalfa), leading to annual guinea pig roasts, leading to a concentration of vectors on a small subpopulation of animals maintained for reproduction, can propel T. cruzi through vector colonies and create a considerable force of infection for a pathogen whose transmission might otherwise fizzle out.
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Registered trials
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