ArticleMolecular biology and evolution2015
Mitogenomic Meta-Analysis Identifies Two Phases of Migration in the History of Eastern Eurasian Sheep.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Unveiling maternal lineages of Sopas sheep: insights from complete mitochondrial DNA cytochrome b (Cyt b) and displacement loop (D-loop) analyses.Tropical animal health and production · 2026Article
- Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis.Journal of advanced research · 2026Article
- Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations.Animals : an open access journal from MDPI · 2026Article
- Integrated mitogenome and Y chromosome analysis untangles the complex origin of African pigs.iScience · 2026Article
- Genetic Diversity and Population Structure of Fat-Tailed Coarse-Wooled Sheep BreedsVeterinary sciences · 2025Article
- Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mouflon and Domestic Sheep Phylogeny: Ancestry, Domestication, and Evolutionary Dynamics.Life (Basel, Switzerland) · 2025Review
- Three Complete Mitochondrial Genomes ofBiology · 2025Article
- Kazakh Tobet dogs in the genomic landscape: refining the history of livestock guardian breeds.BMC biology · 2025Article
- Genomic analyses of Asiatic Mouflon in Iran provide insights into the domestication and evolution of sheep.Genetics, selection, evolution : GSE · 2025Article
- Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations.Science China. Life sciences · 2025Review
- Whole-Genome Resequencing in Sheep: Applications in Breeding, Evolution, and Conservation.Genes · 2025Review
- Molecular Genetic Assessment Aids in Clarifying Phylogenetic Status of Iranian Kerman Wild Sheep.Animals : an open access journal from MDPI · 2025Article
- Revealing the genetic basis of coat color in Tibetan sheep through selective sweep and transcriptomic analyses.Frontiers in veterinary science · 2025Article
- Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep.Journal of animal science and biotechnology · 2024Article
- The Population History of Domestic Sheep Revealed by Paleogenomes.Molecular biology and evolution · 2024Article
- Characterizing the Phan Rang Sheep: A First Look at the Y Chromosome, Mitochondrial DNA, and Morphometrics.Animals : an open access journal from MDPI · 2024Article
- Genomic structural variation contributes to evolved changes in gene expression in high-altitude Tibetan sheep.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds.BMC genomics · 2024Article
- Population Genomic History of the Endangered Anatolian and Cyprian Mouflons in Relation to Worldwide Wild, Feral, and Domestic Sheep Lineages.Genome biology and evolution · 2024Article
23 more citing papers are in PubMed but not listed here.
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25 authors.
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Abstract
Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete and 875 partial mitogenomic sequences, and performed a meta-analysis of these and published ovine mitochondrial DNA sequences (n = 3,229) across Eurasia. We inferred that O. orientalis and O. musimon share the most recent female ancestor with O. aries at approximately 0.790 Ma (95% CI: 0.637-0.934 Ma) during the Middle Pleistocene, substantially predating the domestication event (∼8-11 ka). By reconstructing historical variations in effective population size, we found evidence of a rapid population increase approximately 20-60 ka, immediately before the Last Glacial Maximum. Analyses of lineage expansions showed two sheep migratory waves at approximately 4.5-6.8 ka (lineages A and B: ∼6.4-6.8 ka; C: ∼4.5 ka) across eastern Eurasia, which could have been influenced by prehistoric West-East commercial trade and deliberate mating of domestic and wild sheep, respectively. A continent-scale examination of lineage diversity and approximate Bayesian computation analyses indicated that the Mongolian Plateau region was a secondary center of dispersal, acting as a "transportation hub" in eastern Eurasia: Sheep from the Middle Eastern domestication center were inferred to have migrated through the Caucasus and Central Asia, and arrived in North and Southwest China (lineages A, B, and C) and the Indian subcontinent (lineages B and C) through this region. Our results provide new insights into sheep domestication, particularly with respect to origins and migrations to and from eastern Eurasia.
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