ArticleThe American journal of clinical nutrition2015
Cesarean delivery and metabolic risk factors in young adults: a Brazilian birth cohort study.
Article in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Caesarean section and obesity in young adult offspring: Update of a systematic review with meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Sex modulates the long-term effects of delivery mode on microbiota-gut barrier crosstalk and colitis susceptibility in mice.Gut microbes · 2026Article
- Cesarean delivery and metabolic health and inflammation biomarkers during mid-childhood and early adolescence.Pediatric research · 2022Article
- Review
- A Metabolomics Approach to Screening for Autism Risk in the Children's Autism Metabolome Project.Autism research : official journal of the International Society for Autism Research · 2020Article
- Association of Birth by Cesarean Delivery With Obesity and Type 2 Diabetes Among Adult Women.JAMA network open · 2020Article
- Neonatal oral fluid as a transmission route for bifidobacteria to the infant gut immediately after birth.Scientific reports · 2019Article
- The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort.PloS one · 2019Article
- Roles of Birth Mode and Infant Gut Microbiota in Intergenerational Transmission of Overweight and Obesity From Mother to Offspring.JAMA pediatrics · 2018Observational
- Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk.International journal of obesity (2005) · 2018Article
- Gender and social mobility modify the effect of birth weight on total and central obesity.Nutrition journal · 2017Article
- Does vaginal delivery mitigate or strengthen the intergenerational association of overweight and obesity? Findings from the Boston Birth Cohort.International journal of obesity (2005) · 2017Article
- Preconception Care: A New Standard of Care within Maternal Health Services.BioMed research international · 2016Review
- The Maternal Infant Microbiome: Considerations for Labor and Birth.MCN. The American journal of maternal child nursingArticle
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCesarean delivery (CD) perturbs the assembly of the neonatal gut microbiome and has been associated with child and adult obesity. However, it is still unknown whether CD is associated with metabolic risk factors in young adults.
objectiveWe investigated the association of CD and metabolic risk factors in young adults in a cohort study who were 23-25 y of age at follow-up.
designWe used data from a cohort study in Ribeirão Preto, Brazil. Baseline data on 6827 singleton pregnancies were collected in 1978-1979, and a sample of 2063 subjects were followed up 23-25 y later (2002-2004). Information on the type of delivery, birth weight, maternal age, parity, maternal schooling, and maternal smoking was obtained after birth. Anthropometric data, biochemical measurements, and information on participant schooling and smoking history were collected at 23-25 y of age. A linear regression was performed to assess the association between CD and biochemical measurements in early adulthood, controlling for a minimum set of confounders that were identified in a directed acyclic graph.
resultsThe mean ± SD age of the subjects was 23.9 ± 0.71 y, and 51.8% of the sample were women. The CD rate was 32.0% and was more common in older (P < 0.001) and more educated mothers (P < 0.001). Compared with vaginal delivery, CD was associated with higher body mass index (BMI) after multivariable adjustment (P < 0.001) but not with glucose, homeostasis model assessment of insulin resistance, the quantitative insulin-sensitivity check index, total cholesterol, LDL cholesterol, HDL cholesterol, or triglycerides (all P > 0.05).
conclusionIn our sample of Brazilian adults, CD was associated with higher BMI but not with other metabolic risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.