Trial reportSleep2015
The Effects of Sleep Continuity Disruption on Positive Mood and Sleep Architecture in Healthy Adults.
Trial report in Sleep, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2023Pooled it
- Sleep and affect: A conceptual review.Sleep medicine reviews · 2022Pooled it
- Self-reported poor quality of sleep in solid organ transplant: A systematic review.Transplantation reviews (Orlando, Fla.) · 2021Pooled it
- Trial
- A phase 1 double-blind, placebo-controlled study of zuranolone (SAGE-217) in a phase advance model of insomnia in healthy adults.Human psychopharmacology · 2022Trial
- Impact of exercise on older adults' mood is moderated by sleep and mediated by altered brain connectivity.Social cognitive and affective neuroscience · 2020Trial
- Does online insomnia treatment reduce depressive symptoms? A randomized controlled trial in individuals with both insomnia and depressive symptoms.Psychological medicine · 2019Trial
- Disrupting Sleep: The Effects of Sleep Loss on Psychotic Experiences Tested in an Experimental Study With Mediation Analysis.Schizophrenia bulletin · 2018Trial
- Aging disrupts the temporal organization of slow oscillations beyond density reduction.PNAS nexus · 2026Article
- Sleep dependent autonomic correlates of affect and arousal in younger and older adults.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Estradiol and non-REM sleep attenuate physiological and emotional responses to social-evaluative stress in healthy women.BMC medicine · 2025Article
- Older injured adults reported sleep disturbances: a cross-sectional study.Journal of patient-reported outcomes · 2025Article
- Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.Pediatric research · 2025Article
- NREM Sleep Oscillations Are Associated With Anxiety and Negative Affect in Young Adults.Journal of sleep research · 2025Article
- Investigating the impact of electroconvulsive therapy on brain networks and sleep: an observational study protocol.BMJ open · 2025Article
- Daily, prospective associations between sleep architecture and affect: insights from Bayesian multilevel compositional data analysis.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- Sleep Deprivation Selectively Impairs Interpersonal Trust in Different Social Scenarios: Evidence from the Social Mindfulness Paradigm.Nature and science of sleep · 2025Article
- From surviving to thriving: How sleep, physical activity, and diet shape well-being in young adults.PloS one · 2025Article
- Effects of Traumatic Brain Injury on the Orexin/Hypocretin System.Neurotrauma reports · 2025Review
- Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action.Current psychiatry reports · 2024Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveThe purpose of this study was to test an experimental model of the effects of sleep continuity disturbance on sleep architecture and positive mood in order to better understand the mechanisms linking insomnia and depression.
designParticipants were randomized to receive 3 consecutive nights of sleep continuity disruption via forced nocturnal awakenings (FA, n = 21), or one of two control conditions: restricted sleep opportunity (RSO, n = 17) or uninterrupted sleep (US, n = 24).
settingThe study was set in an inpatient clinical research suite.
participantsHealthy, good-sleeping men and women were included. MEASUREMENT AND
resultsPolysomnography was used to measure sleep architecture, and mood was assessed via self-report each day. Compared to restricted sleep opportunity controls, forced awakenings subjects had significantly less slow wave sleep (P < 0.05) after the first night of sleep deprivation, and significantly lower positive mood (P < 0.05) after the second night of sleep deprivation. The differential change in slow wave sleep statistically mediated the observed group differences in positive mood (P = 0.002).
conclusionsTo our knowledge, this is the first human experimental study to demonstrate that, despite comparable reductions in total sleep time, partial sleep loss from sleep continuity disruption is more detrimental to positive mood than partial sleep loss from delaying bedtime, even when controlling for concomitant increases in negative mood. With these findings, we provide temporal evidence in support of a putative biologic mechanism (slow wave sleep deficit) that could help explain the strong comorbidity between insomnia and depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.