Evidence map›Paper›PMID 26085109›Full record

ReviewAdvanced healthcare materials2015

Recent Advances in Targeted, Self-Assembling Nanoparticles to Address Vascular Damage Due to Atherosclerosis.

Eun Ji Chung, Matthew Tirrell

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
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  7. Targeted polyelectrolyte complex micelles treat vascular complications in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Review
  9. Article
  10. Calcium-binding nanoparticles for vascular disease.Regenerative engineering and translational medicine · 2019
    Article
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  13. Review
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  15. Article
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  18. Article
  19. Targeting and therapeutic peptides in nanomedicine for atherosclerosis.Experimental biology and medicine (Maywood, N.J.) · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eun Ji ChungInstitute for Molecular Engineering, University of Chicago, 5747 S. Ellis Ave., Chicago, IL, 60637, USA.
Matthew TirrellInstitute for Molecular Engineering, University of Chicago, 5747 S. Ellis Ave., Chicago, IL, 60637, USA.
University of Chicago · US

Funding

Multimodal Peptide Amphiphile Micelles for AtherosclerosisK99HL124279 · NHLBI · UNIVERSITY OF CHICAGO · PI CHUNG, EUN JI PAIGE · 2015 to 2016
$180k
NHLBI NIH HHS K99 HL124279NHLBI NIH HHS K99HL124279
6 · The paper itself

Abstract

Self-assembling nanoparticles functionalized with targeting moieties have significant potential for atherosclerosis nanomedicine. While self-assembly allows the easy construction (and degradation) of nanoparticles with therapeutic or diagnostic functionality, or both, the targeting agent can direct them to a specific molecular marker within a given stage of the disease. Therefore, supramolecular nanoparticles have been investigated in the last decade as molecular imaging agents or explored as nanocarriers that can decrease the systemic toxicity of drugs by producing accumulation predominantly in specific tissues of interest. In this Progress Report, the pathogenesis of atherosclerosis and the damage caused to vascular tissue are described, as well as the current diagnostic and treatment options. An overview of targeted strategies using self-assembling nanoparticles is provided, including liposomes, high density lipoproteins, protein cages, micelles, proticles, and perfluorocarbon nanoparticles. Finally, an overview is given of current challenges, limitations, and future applications for personalized medicine in the context of atherosclerosis of self-assembling nanoparticles.

Indexed as

AnimalsAtherosclerosisBlood VesselsHumansNanomedicineNanoparticlesPeptidesPeptidesatherosclerosisliposomesnanoparticlesself-assemblyvascular damage

Identifiers

PMID26085109
PMCPMC4760622
OpenAlexW1617274718

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.