ArticleScientific reports2015
Overexpression of Tyrosine hydroxylase and Dopa decarboxylase associated with pupal melanization in Spodoptera exigua.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- How a Melanism Mutant Responds to Different Temperatures: A Case Study in Ladybird BeetleEcology and evolution · 2025Article
- Transcriptome-Wide Identification of Neuropeptides and Neuropeptide Receptors in the Twenty-Eight-Spotted LadybirdInsects · 2025Article
- DOPA Decarboxylase (DDC) in Pacific Oysters: Characterization and Role in Tyrosine Metabolism and Melanogenesis.Marine biotechnology (New York, N.Y.) · 2025Article
- Article
- Tyrosine Hydroxylase and DOPA Decarboxylase Are Associated With Pupal Melanization During Larval-Pupal Transformation inFrontiers in physiology · 2022Article
- Suppression of Calcineurin Enhances the Toxicity of Cry1Ac toFrontiers in microbiology · 2021Article
- Transcriptome Analysis ofFrontiers in endocrinology · 2021Article
- Supplemental Sugar Is Required for Sex Pheromone Biosynthesis inFrontiers in physiology · 2020Article
- The Role of the Dopamine Melanin Pathway in the Ontogeny of Elytral Melanization inFrontiers in physiology · 2019Article
- Molecular and Functional Characterization of Odorant Binding Protein 7 From the Oriental Fruit MothFrontiers in physiology · 2018Article
- Specific Binding Protein ABCC1 Is Associated With Cry2Ab Toxicity inFrontiers in physiology · 2018Article
- Transcriptomic Responses to Different Cry1Ac Selection Stresses inFrontiers in physiology · 2018Article
- Isolation and functional identification of three cuticle protein genes during metamorphosis of the beet armyworm, Spodoptera exigua.Scientific reports · 2017Article
- Tsetse fly tolerance to T. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland.BMC genomics · 2016Article
- Tyrosine Hydroxylase is crucial for maintaining pupal tanning and immunity in Anopheles sinensis.Scientific reports · 2016Article
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Authors and funding
3 authors.
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Abstract
Melanism has been found in a wide range of species, but the molecular mechanisms involved remain largely elusive. In this study, we studied the molecular mechanisms of the pupal melanism in Spodoptera exigua. The full length cDNA sequences of tyrosine hydroxylase (TH) and dopa decarboxylase (DDC), two key enzymes in the biosynthesis pathway of melanin, were cloned, and their temporal expression patterns in the integument were compared during the larval-pupal metamorphosis process of the S. exigua wild type (SEW) and melanic mutant (SEM) strains. No amino acid change in the protein sequence of TH and DDC was found between the two strains. Both DDC and TH were significantly over-expressed in the integument of the SEM strain at late-prepupa and 0 h pupa, respectively, compared with those of the SEW strain. Feeding 5(th) instar larvae of SEM with diets incorporated with 1 mg/g of the DDC inhibitor L-α-Methyl-DOPA and 0.75 mg/g of the TH inhibitor 3-iodo-tyrosine (3-IT) resulted in 20% pupae with partially-rescued phenotype and 68.2% of pupae with partially- or fully-rescued phenotype, respectively. These results indicate that overexpressions of TH and DDC are involved in the pupal melanization of S. exigua.
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