Trial reportArthritis research & therapy2015
Stress Doppler echocardiography for early detection of systemic sclerosis-associated pulmonary arterial hypertension.
Trial report in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01387035 (Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Diagnostic accuracy of transthoracic echocardiography for pulmonary hypertension: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Abnormal pulmonary artery systolic pressure response after exercise in systemic sclerosis patients: A PRISMA-compliant meta-analysis.Medicine · 2019Pooled it
- Exercise echocardiography for the assessment of pulmonary hypertension in systemic sclerosis: a systematic review.Arthritis research & therapy · 2016Pooled it
- Echocardiography-Derived Exercise Pulmonary Hypertension and Longitudinal Changes in Pulmonary Artery Pressures in Systemic Sclerosis: A Non-Invasive Assessment for Risk Stratification.Pulmonary circulation · 2026Article
- Prevalence, molecular mechanisms and diagnostic approaches to pulmonary arterial hypertension in connective tissue diseases.Rheumatology international · 2025Review
- A pulmonary hypertension targeted algorithm to improve referral to right heart catheterization: A machine learning approach.Computational and structural biotechnology journal · 2024Article
- Exercise pulmonary hypertension in patients with systemic sclerosis based on updated guidelines.Scientific reports · 2024Article
- Use of exercise tests in screening for pulmonary arterial hypertension in systemic sclerosis: A systematic literature review.Journal of scleroderma and related disorders · 2024Article
- Functional disability and health-related quality of life among systemic sclerosis patients in Bangladesh.BMC rheumatology · 2022Article
- Exercise-Induced Pulmonary Hypertension Is Associated with High Cardiovascular Risk in Patients with HIV.Journal of clinical medicine · 2022Article
- High prevalence of occult left ventricular diastolic dysfunction detected by exercise stress test in systemic sclerosis.Scientific reports · 2022Article
- Low-Dose Dobutamine Stress Echocardiography for the Early Detection of Pulmonary Arterial Hypertension in Selected Patients with Systemic Sclerosis Whose Resting Echocardiography Is Non-Diagnostic for Pulmonary Hypertension.Journal of clinical medicine · 2021Article
- The Role of Exercise Doppler Echocardiography to Unmask Pulmonary Arterial Hypertension in Selected Patients with Systemic Sclerosis and Equivocal Baseline Echocardiographic Values for Pulmonary Hypertension.Diagnostics (Basel, Switzerland) · 2021Article
- Article
- Interleukin-32 in systemic sclerosis, a potential new biomarker for pulmonary arterial hypertension.Arthritis research & therapy · 2020Article
- A review of exercise pulmonary hypertension in systemic sclerosis.Journal of scleroderma and related disorders · 2019Review
- Potential role of exercise echocardiography and right heart catheterization in the detection of early pulmonary vascular disease in patients with systemic sclerosis.Journal of scleroderma and related disorders · 2019Review
- Screening for pulmonary arterial hypertension in systemic sclerosis.European respiratory review : an official journal of the European Respiratory Society · 2019Article
- Systolic pulmonary artery pressure assessed during routine exercise Doppler echocardiography: insights of a real-world setting in patients with elevated pulmonary pressures.The international journal of cardiovascular imaging · 2018Article
- An Update on Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: a Review of the Current Literature.Current rheumatology reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn patients with systemic sclerosis (SSc), associated pulmonary arterial hypertension (SSc-APAH) is the leading cause of death. The objective of this prospective screening study was to analyse sensitivity and specificity of stress Doppler echocardiography (SDE) in detecting pulmonary hypertension (PH).
methodsPulmonary artery pressures and further parameters of PH were assessed by echocardiography and right heart catheterisation (RHC) at rest and during exercise in patients with SSc. Investigators of RHC were blinded to the results of non-invasive measurements.
resultsOf 76 patients with SSc (64 were female and mean age was 58±14 years), 22 (29 %) had manifest PH confirmed by RHC: four had concomitant left heart diseases, three had lung diseases, and 15 had SSc-APAH. Echocardiography at rest missed PH diagnosis in five of 22 patients with PH when a cutoff value for systolic pulmonary arterial pressure (PASP) was more than 40 mm Hg at rest. The sensitivity of echocardiography at rest was 72.7 % (95 % confidence interval (CI) 0.52-0.88), and specificity was 88.2 % (95 % CI 0.78-0.95). When a cutoff value for PASP was more than 45 mm Hg during low-dose exercise, SDE missed PH diagnosis in one of the 22 patients with PH and improved sensitivity to 95.2 % (95 % CI 0.81-1.0) but reduced specificity to 84.9 % (95 % CI 0.74-0.93). Reduction of specificity was partly due to concomitant left heart disease.
conclusionsThe results of this prospective cross-sectional study using RHC as gold standard in all patients showed that SDE markedly improved sensitivity in detecting manifest PH to 95.2 % compared with 72.7 % using echocardiography at rest only. Thus, for PH screening in patients with SSc, echocardiography should be performed at rest and during exercise.
trial registrationClinicalTrials.gov NCT01387035. Registered 29 June 2011.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.