ArticleJournal of neurophysiology2015
Fidelity of frequency and phase entrainment of circuit-level spike activity during DBS.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Delay suppression control of β-oscillations: a proposal for dual-target adaptive deep brain stimulation on STN-GPe network model.Biological cybernetics · 2025Article
- Utilising activity patterns of a complex biophysical network model to optimise intra-striatal deep brain stimulation.Scientific reports · 2024Article
- Simulated dataset on coordinated reset stimulation of homogeneous and inhomogeneous networks of excitatory leaky integrate-and-fire neurons with spike-timing-dependent plasticity.Data in brief · 2024Article
- Model-based closed-loop control of thalamic deep brain stimulation.Frontiers in network physiology · 2024Article
- Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus.Nature communications · 2022Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli.PLoS computational biology · 2022Article
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- Longitudinal analysis of local field potentials recorded from directional deep brain stimulation lead implants in the subthalamic nucleus.Journal of neural engineering · 2021Article
- Suppressing synchronous firing of epileptiform activity by high-frequency stimulation of afferent fibers in rat hippocampus.CNS neuroscience & therapeutics · 2021Article
- Revisiting the "Paradox of Stereotaxic Surgery": Insights Into Basal Ganglia-Thalamic Interactions.Frontiers in systems neuroscience · 2021Review
- Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.Brain : a journal of neurology · 2020Article
- Frequency-dependent spike-pattern changes in motor cortex during thalamic deep brain stimulation.Journal of neurophysiology · 2020Article
- Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density.Journal of neuroscience research · 2019Article
- [A design of raster plot for illustrating dynamic neuronal activity during deep brain stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Innovations in electrical stimulation harness neural plasticity to restore motor function.Bioelectronics in medicine · 2018Article
- Frequency-dependent antidromic activation in thalamocortical relay neurons: effects of synaptic inputs.Journal of neural engineering · 2018Article
- The History and Horizons of Microscale Neural Interfaces.Micromachines · 2018Article
- Deep brain stimulation induces sparse distributions of locally modulated neuronal activity.Scientific reports · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
High-frequency stimulation is known to entrain spike activity downstream and upstream of several clinical deep brain stimulation (DBS) targets, including the cerebellar-receiving area of thalamus (VPLo), subthalamic nucleus (STN), and globus pallidus (GP). Less understood are the fidelity of entrainment to each stimulus pulse, whether entrainment patterns are stationary over time, and how responses differ among DBS targets. In this study, three rhesus macaques were implanted with a single DBS lead in VPLo, STN, or GP. Single-unit spike activity was recorded in the resting state in motor cortex during VPLo DBS, in GP during STN DBS, and in STN and pallidal-receiving area of motor thalamus (VLo) during GP DBS. VPLo DBS induced time-locked spike activity in 25% (n = 15/61) of motor cortex cells, with entrained cells following 7.5 ± 7.4% of delivered pulses. STN DBS entrained spike activity in 26% (n = 8/27) of GP cells, which yielded time-locked spike activity for 8.7 ± 8.4% of stimulus pulses. GP DBS entrained 67% (n = 14/21) of STN cells and 32% (n = 19/59) of VLo cells, which showed a higher fraction of pulses effectively inhibiting spike activity (82.0 ± 9.6% and 86.1 ± 16.6%, respectively). Latency of phase-locked spike activity increased over time in motor cortex (58%, VPLo DBS) and to a lesser extent in GP (25%, STN DBS). In contrast, the initial inhibitory phase observed in VLo and STN during GP DBS remained stable following stimulation onset. Together, these data suggest that circuit-level entrainment is low-pass filtered during high-frequency stimulation, most notably for glutamatergic pathways. Moreover, phase entrainment is not stationary or consistent at the circuit level for all DBS targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.