ArticleJournal of neurophysiology2015
Neuronal variability in orbitofrontal cortex during economic decisions.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Using economic value signals from primate prefrontal cortex in neuro-engineering applications.Journal of neural engineering · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuronal Activity in the Gustatory Cortex during Economic Choice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Orbitofrontal high-gamma reflects spike-dissociable value and decision mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Behavioral read-out from population value signals in primate orbitofrontal cortex.Nature neuroscience · 2023Article
- Action-rule-based cognitive control enables efficient execution of stimulus-response conflict tasks: a model validation of Simon task performance.Frontiers in human neuroscience · 2023Article
- Logistic analysis of choice data: A primer.Neuron · 2022Review
- The case against economic values in the orbitofrontal cortex (or anywhere else in the brain).Behavioral neuroscience · 2021Article
- Excitatory-inhibitory tone shapes decision strategies in a hierarchical neural network model of multi-attribute choice.PLoS computational biology · 2021Article
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- Partial Adaptation to the Value Range in the Macaque Orbitofrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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- Article
- Review
- Optimal coding and neuronal adaptation in economic decisions.Nature communications · 2017Article
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- Decision Making and Sequential Sampling from Memory.Neuron · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Neuroeconomic models assume that economic decisions are based on the activity of offer value cells in the orbitofrontal cortex (OFC), but testing this assertion has proven difficult. In principle, the decision made on a given trial should correlate with the stochastic fluctuations of these cells. However, this correlation, measured as a choice probability (CP), is small. Importantly, a neuron's CP reflects not only its individual contribution to the decision (termed readout weight), but also the intensity and the structure of correlated variability across the neuronal population (termed noise correlation). A precise mathematical relation between CPs, noise correlations, and readout weights was recently derived by Haefner and colleagues (Haefner RM, Gerwinn S, Macke JH, Bethge M. Nat Neurosci 16: 235-242, 2013) for a linear decision model. In this framework, concurrent measurements of noise correlations and CPs can provide quantitative information on how a population of cells contributes to a decision. Here we examined neuronal variability in the OFC of rhesus monkeys during economic decisions. Noise correlations had similar structure but considerably lower strength compared with those typically measured in sensory areas during perceptual decisions. In contrast, variability in the activity of individual cells was high and comparable to that recorded in other cortical regions. Simulation analyses based on Haefner's equation showed that noise correlations measured in the OFC combined with a plausible readout of offer value cells reproduced the experimental measures of CPs. In other words, the results obtained for noise correlations and those obtained for CPs taken together support the hypothesis that economic decisions are primarily based on the activity of offer value cells.
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