Evidence map›Paper›PMID 26084867›Full record

ArticleLeukemia2016

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.

S He, B Malik, D Borkin, H Miao, S Shukla, K Kempinska, T Purohit, J Wang, L Chen, B Parkin and 5 more

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

S HeDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
B MalikDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
D BorkinDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
H MiaoDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
S ShuklaDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
K KempinskaDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
T PurohitDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
J WangDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
L ChenDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
B ParkinDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
S N MalekDivision of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor MI, USA.
G Danet-DesnoyersDivision of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
A G MunteanDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
T CierpickiDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
J GrembeckaDepartment of Pathology, University of Michigan, Ann Arbor MI, USA.
University of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

Development of novel anti-leukemia agents targeting the menin-MLL interactionR01CA160467 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GREMBECKA, JOLANTA · 2011 to 2021
$3.4M
NCI NIH HHS 1R01CA160467NCI NIH HHS R01 CA160467
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell Line, TumorCell Transformation, NeoplasticHistone-Lysine N-MethyltransferaseHumansLeukemia, Biphenotypic, AcuteMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionProto-Oncogene ProteinsHistone-Lysine N-MethyltransferaseKMT2A protein, humanMEN1 protein, humanMLL-AF4 fusion protein, humanMLL-AF9 fusion protein, humanMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionProto-Oncogene Proteins

Identifiers

PMID26084867
PMCPMC4830728
OpenAlexW1560166507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.