ArticleCancer discovery2015
A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.
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Article in Cancer discovery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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56citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Pooled it
- Exploring genetic diversity in genome-wide association studies and polygenic risk scores in the admixed Brazilian population.Genetics and molecular biology · 2026Article
- Molecular basis of NFIB-mediated regulation of oncogenic transcription.Nucleic acids research · 2025Article
- Molecular pathology of adenoid cystic carcinoma.Histology and histopathology · 2025Review
- miR-490-5p inhibits the progression of osteosarcoma by targeting HDAC2.Translational cancer research · 2025Article
- Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.Cancer epidemiology · 2024Article
- LncRNAs as potential prognosis/diagnosis markers and factors driving drug resistance of osteosarcoma, a review.Frontiers in endocrinology · 2024Review
- CEP55, serving as a diagnostic marker gene for osteosarcoma, triggers the JAK2-STAT3-MMPs axis.Annals of medicine and surgery (2012) · 2024Article
- Children's Oncology Group's 2023 blueprint for research: Epidemiology.Pediatric blood & cancer · 2023Article
- Downregulation of miR-182-5p by NFIB promotes NAD+ salvage synthesis in colorectal cancer by targeting NAMPT.Communications biology · 2023Article
- Osteosarcoma transcriptome data exploration reveals STC2 as a novel risk indicator in disease progression.BMC medical genomics · 2023Article
- Article
- Whole exome sequencing identified a novelFrontiers in oncology · 2022Article
- Hepatocyte-Specific Knock-Out of Nfib Aggravates Hepatocellular Tumorigenesis via Enhancing Urea Cycle.Frontiers in molecular biosciences · 2022Article
- Long noncoding RNA SNHG4: a novel target in human diseases.Cancer cell international · 2021Review
- Identification of 6 gene markers for survival prediction in osteosarcoma cases based on multi-omics analysis.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Direct conversion of osteosarcoma to adipocytes by targeting TNIK.JCI insight · 2021Article
- Associations of Socioeconomic Status, Public vs Private Insurance, and Race/Ethnicity With Metastatic Sarcoma at Diagnosis.JAMA network open · 2020Article
- The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma.Bioscience reports · 2020Article
- Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma.JAMA oncology · 2020Article
Corrections and comments
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Authors and funding
52 authors at 15 institutions in 6 countries.
Lisa MirabelloDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland. mirabellol@mail.nih.gov.
Roelof KosterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Branden S MoriarityDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota. Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Logan G SpectorDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
Paul S MeltzerCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Joy GaryLaboratory of Cancer Biology and Genetics, NCI, NIH, Bethesda, Maryland; College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.
Orestis A PanagiotouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
David LargaespadaDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota. Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.
Zhaoming WangCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Julie M Gastier-FosterNationwide Children's Hospital, and The Ohio State University Department of Pathology and Pediatrics, Columbus, Ohio.
Richard GorlickAlbert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, New York.
Chand KhannaCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Silvia Regina Caminada de ToledoPediatric Oncology Institute, GRAACC/UNIFESP, São Paulo SP, Brazil.
Antonio S PetrilliPediatric Oncology Institute, GRAACC/UNIFESP, São Paulo SP, Brazil.
Ana Patiño-GarciaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Luis SierrasesúmagaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Fernando LecandaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Irene L AndrulisUniversity of Toronto, Litwin Centre for Cancer Genetics, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Jay S WunderUniversity of Toronto, Litwin Centre for Cancer Genetics, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Nalan GokgozUniversity of Toronto, Litwin Centre for Cancer Genetics, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Massimo SerraLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Claudia HattingerLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Piero PicciLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Katia ScotlandiLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Adrienne M FlanaganUniversity College London Cancer Institute, London, United Kingdom. Royal National Orthopaedic Hospital National Health Service Trust, Stanmore, Middlesex, United Kingdom.
Roberto TiraboscoRoyal National Orthopaedic Hospital National Health Service Trust, Stanmore, Middlesex, United Kingdom.
Maria Fernanda AmaryRoyal National Orthopaedic Hospital National Health Service Trust, Stanmore, Middlesex, United Kingdom.
Dina HalaiRoyal National Orthopaedic Hospital National Health Service Trust, Stanmore, Middlesex, United Kingdom.
Mandy L BallingerPeter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
David M ThomasThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Sean DavisCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
Donald A BarkauskasDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Neyssa MarinaStanford University and Lucile Packard Children's Hospital, Palo Alto, California.
Lee HelmanCenter for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.
George M OttoMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Kelsie L BecklinDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.
Natalie K WolfDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.
Madison T WegMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Margaret TuckerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Sholom WacholderDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Joseph F BolandCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Belynda D HicksCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Aurelie VogtCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Laurie BurdettCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Meredith YeagerCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
Sharon A SavageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
National Cancer Institute · USUniversity of Minnesota · USLeidos (United States) · USOrthopedic Institute · USRoyal National Orthopaedic Hospital · GBClinica Universidad de Navarra · ESLunenfeld-Tanenbaum Research Institute · CAFundação de Apoio à Universidade Federal de São Paulo · BRCancer Genetics (United States) · USChildren's Hospital at Montefiore · USGarvan Institute of Medical Research · AULucile Packard Children's Hospital · USNationwide Children's Hospital · USPeter MacCallum Cancer Centre · AUUniversity of Southern California · US
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MWomen's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4MCharacterization of the Osteosarcoma GenomeZIABC011328 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MELTZER, PAUL S. · 2010 to 2025
$28.0MFunctional Genomics of SarcomaZIABC010759 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MELTZER, PAUL S. · 2009 to 2025
$22.3MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MSleeping Beauty for uncovering cancer genes in miceR01CA113636 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW · 2006 to 2016
$2.5MGenetic Epidemiology of OsteosarcomaU01CA122371 · NCI · UNIVERSITY OF MINNESOTA · PI SPECTOR, LOGAN G. · 2007 to 2010
$1.7MIntramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA113636NCI NIH HHS U01 CA122371NCI NIH HHS U01CA122371NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U10 CA98543NCI NIH HHS U24 CA114766
Abstract
unlabelledMetastasis is the leading cause of death in patients with osteosarcoma, the most common pediatric bone malignancy. We conducted a multistage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determine whether germline genetic variation contributes to risk of metastasis. We identified an SNP, rs7034162, in NFIB significantly associated with metastasis in European osteosarcoma cases, as well as in cases of African and Brazilian ancestry (meta-analysis of all cases: P = 1.2 × 10(-9); OR, 2.43; 95% confidence interval, 1.83-3.24). The risk allele was significantly associated with lowered NFIB expression, which led to increased osteosarcoma cell migration, proliferation, and colony formation. In addition, a transposon screen in mice identified a significant proportion of osteosarcomas harboring inactivating insertions in Nfib and with lowered NFIB expression. These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene. SIGNIFICANCE: Metastasis at diagnosis in osteosarcoma is the leading cause of death in these patients. Here we show data that are supportive for the NFIB locus as associated with metastatic potential in osteosarcoma.
Indexed as
Genetic VariationGenome-Wide Association StudyAllelesAnimalsBone NeoplasmsCell Line, TumorCell MovementCell ProliferationChromosomes, Human, Pair 9Disease Models, AnimalDNA Transposable ElementsGene Expression Regulation, NeoplasticGenetic Association StudiesGenetic LinkageGenetic Predisposition to DiseaseGenotypeDNA Transposable ElementsNFIB protein, humanNFI Transcription Factors
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