ReviewNew solutions : a journal of environmental and occupational health policy : NS2015
Perfluorinated Alkyl Substances: Emerging Insights Into Health Risks.
Review in New solutions : a journal of environmental and occupational health policy : NS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- Association between perfluoroalkyl substances exposure and thyroid function in adults: A meta-analysis.PloS one · 2018Pooled it
- Article
- Unsupervised dietary-behavioral profiling identifies PFAS (per- and polyfluoroalkyl substances) and metal exposure patterns in Korean adults.Scientific reports · 2026Article
- Single versus mixed perfluorinated compound exposures and cardiovascular disease risk: mechanistic insights from cross-sectional data and molecular interactions.Archives of toxicology · 2026Article
- Article
- Toxicogenomic Characterization of Perfluorooctanoic Acid-Associated Bladder Carcinogenesis.Cell biology and toxicology · 2026Article
- Impact of Perfluorinated Organic Acids on Bacterial Ice Nucleators.The journal of physical chemistry. B · 2026Article
- Treatment of Per- and Polyfluoroalkyl Substances (PFAS)-Contaminated Hypersaline Brine by Membrane Distillation.ACS environmental Au · 2026Article
- Per- and Polyfluoroalkyl Substances Induce Cardiotoxicity and Alter Protein Profiles of Extracellular Matrix, Metabolism, and Mitochondrial Function in Human Cardiomyocytes.Chemical research in toxicology · 2026Article
- Centripetal Axonal Transport as a Gateway to the CNS for Veterinary Antiparasitics: Bypassing the Blood-Brain Barrier, Clinical Impact in Vulnerable Age Groups, and the Potential Facilitating Role of PFAS.Journal of toxicology · 2026Review
- Impact of PFAS exposure on lipid metabolic pathways: mechanisms and implicatins in carcinogenesis.Frontiers in toxicology · 2026Review
- Paper-Based Electroanalysis for Emerging Pollutant Detection.ACS electrochemistry · 2025Review
- Assessment of water pollution and environmental impacts in the Pineios river basin before and after extreme flood events in Thessaly, Greece.Environmental science and pollution research international · 2025Article
- Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review.Toxics · 2025Review
- Evaluating the environmental occurrence of per- and polyfluoroalkyl substances (PFAS) and potential exposure risk for recreational shellfish harvesters in the Great Bay Estuary, New Hampshire.The Science of the total environment · 2025Article
- Improving PFAS Rejection by Ultrafiltration Membranes via Polyelectrolyte Multilayer Coating.Membranes · 2025Article
- Structural Characterization of Dimeric Perfluoroalkyl Carboxylic Acid Using Experimental and Theoretical Ion Mobility Spectrometry Analyses.Journal of the American Society for Mass Spectrometry · 2025Article
- Perfluoroalkyl and Polyfluoroalkyl Substance Detection in Brewed Capsule Coffee.Foods (Basel, Switzerland) · 2025Article
- Research Progress in Current and Emerging Issues of PFASs' Global Impact: Long-Term Health Effects and Governance of Food Systems.Foods (Basel, Switzerland) · 2025Review
- A review of human exposure to PFAS: substantial contribution from seafood.Environmental health and preventive medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Perfluorinated alkyl substances have been in use for over sixty years. These highly stable substances were at first thought to be virtually inert and of low toxicity. Toxicity information slowly emerged on perfluorooctanoic acid and perfluorooctane sulfonate. More than thirty years ago, early studies reported immunotoxicity and carcinogenicity effects. The substances were discovered in blood samples from exposed workers, then in the general population and in community water supplies near U.S. manufacturing plants. Only recently has research publication on perfluorooctanoic acid and perfluorooctane sulfonate intensified. While the toxicology database is still far from complete, carcinogenicity and immunotoxicity now appear to be relevant risks at prevalent exposure levels. Existing drinking water limits are based on less complete evidence that was available before 2008 and may be more than 100-fold too high. As risk evaluations assume that untested effects do not require regulatory attention, the greatly underestimated health risks from perfluorooctanoic acid and perfluorooctane sulfonate illustrate the public health implications of assuming the safety of incompletely tested industrial chemicals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.