SynthesisDiabetes care2015
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.
Synthesis in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial.Diabetologia · 2024Trial
- Macronutrient-specific effect of theJournal of lipid research · 2018Trial
- Morning clock gene expression in young adults of early and late chronotypes.Scientific reports · 2025Article
- Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank.Diabetes care · 2024Article
- Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes.Diabetes & metabolism journal · 2024Review
- Development and validation of a multivariable genotype-informed gestational diabetes prediction algorithm for clinical use in the Mexican population: insights into susceptibility mechanisms.BMJ open diabetes research & care · 2023Article
- Association between triglyceride glucose index and sleep disorders: results from the NHANES 2005-2008.BMC psychiatry · 2023Article
- Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2.Circulation · 2022Article
- Gene-environment interaction between circadian clock gene polymorphisms and job stress on the risk of sleep disturbances.Psychopharmacology · 2022Article
- Observational
- Article
- Ischemic Stroke and Sleep: The Linking Genetic Factors.Cardiology and therapy · 2021Review
- Association between MTNR1B polymorphisms and obesity in African American: findings from the Jackson Heart Study.BMC medical genomics · 2021Article
- Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population.Molecular biology reports · 2021Article
- Genetically Guided Mediterranean Diet for the Personalized Nutritional Management of Type 2 Diabetes Mellitus.Nutrients · 2021Review
- The influence of specific aspects of occupational stress on security guards' health and work ability: detailed extension of a previous study.Arhiv za higijenu rada i toksikologiju · 2020Article
- Review
- Comment on: "Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate".International journal of molecular sciences · 2019Article
- Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report.Diabetes care · 2019Review
- Off the Clock: From Circadian Disruption to Metabolic Disease.International journal of molecular sciences · 2019Review
Corrections and comments
- Erratum issued
Authors and funding
23 authors.
Funding
Abstract
objectiveCommon circadian-related gene variants associate with increased risk for metabolic alterations including type 2 diabetes. However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs10830963, NR1D1-rs2314339) and cardiometabolic traits (fasting glucose [FG], HOMA-insulin resistance, BMI, waist circumference, and HDL-cholesterol) to facilitate personalized recommendations. RESEARCH DESIGN AND
methodsWe conducted inverse-variance weighted, fixed-effect meta-analyses of results of adjusted associations and interactions between dietary intake/sleep duration and selected variants on cardiometabolic traits from 15 cohort studies including up to 28,190 participants of European descent from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.
resultsWe observed significant associations between relative macronutrient intakes and glycemic traits and short sleep duration (<7 h) and higher FG and replicated known MTNR1B associations with glycemic traits. No interactions were evident after accounting for multiple comparisons. However, we observed nominally significant interactions (all P < 0.01) between carbohydrate intake and MTNR1B-rs1387153 for FG with a 0.003 mmol/L higher FG with each additional 1% carbohydrate intake in the presence of the T allele, between sleep duration and CRY2-rs11605924 for HDL-cholesterol with a 0.010 mmol/L higher HDL-cholesterol with each additional hour of sleep in the presence of the A allele, and between long sleep duration (≥9 h) and MTNR1B-rs1387153 for BMI with a 0.60 kg/m(2) higher BMI with long sleep duration in the presence of the T allele relative to normal sleep duration (≥7 to <9 h).
conclusionsOur results suggest that lower carbohydrate intake and normal sleep duration may ameliorate cardiometabolic abnormalities conferred by common circadian-related genetic variants. Until further mechanistic examination of the nominally significant interactions is conducted, recommendations applicable to the general population regarding diet—specifically higher carbohydrate and lower fat composition—and normal sleep duration should continue to be emphasized among individuals with the investigated circadian-related gene variants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.