Evidence map›Paper›PMID 26084342›Full record

Trial reportDiabetes care2015

Metabolic Effects of Exercise Training Among Fitness-Nonresponsive Patients With Type 2 Diabetes: The HART-D Study.

Ambarish Pandey, Damon L Swift, Darren K McGuire, Colby R Ayers, Ian J Neeland, Steven N Blair, Neil Johannsen, Conrad P Earnest, Jarett D Berry, Timothy S Church

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05877196 (Precision Medicine in Alzheimer's Disease), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05877196 narecruitingnot on this mapstarted 2023, after this paper: background citation

Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)

TypeinterventionalSponsorArizona State UniversityRan2023 to 2028Enrolled216ConditionsMild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive DeclineArmsModerate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT), Combined Aerobic Resistance Exercise (CARE)
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ambarish PandeyDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Damon L SwiftDepartment of Kinesiology, East Carolina University, Greenville, NC.
Darren K McGuireDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX.
Colby R AyersDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX.
Ian J NeelandDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Steven N BlairDepartment of Exercise Science, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.
Neil JohannsenSchool of Kinesiology, College of Human Sciences & Education, Louisiana State University, Baton Rouge, LA.
Conrad P EarnestDepartment for Health & Kinesiology, Texas A&M University, College Station, TX.
Jarett D BerryDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX jarett.berry@utsouthwestern.edu.
Timothy S ChurchPreventive Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA.

Funding

Health benefits of Aerobic and Resistance Training in individuals with DiabetesR01DK068298 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CHURCH, TIMOTHY STEPHEN · 2006 to 2009
$2.3M
NIDDK NIH HHS DK-068298NIDDK NIH HHS R01 DK068298
6 · The paper itself

Abstract

objectiveTo evaluate the impact of exercise training (ET) on metabolic parameters among participants with type 2 diabetes mellitus (T2DM) who do not improve their cardiorespiratory fitness (CRF) with training. RESEARCH DESIGN AND

methodsWe studied participants with T2DM participating in the Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes (HART-D) trial who were randomized to a control group or one of three supervised ET groups for 9 months. Fitness response to ET was defined as a change in measured peak absolute oxygen uptake (ΔVO(2peak), in liters per minute) from baseline to follow-up. ET participants were classified based on ΔVO(2peak) into fitness responders (ΔVO(2peak) ≥5%) and nonresponders (ΔVO(2peak) <5%), and changes in metabolic profiles were compared across control, fitness responder, and fitness nonresponder groups.

resultsA total of 202 participants (mean age 57.1 ± 7.9 years, 63% women) were included. Among the exercise groups (n = 161), there was substantial heterogeneity in ΔVO(2peak); 57% had some improvement in CRF (ΔVO(2peak) >0), with only 36.6% having a ≥5% increase in VO(2peak). Both fitness responders and nonresponders (respectively) had significant improvements in hemoglobin A1c and measures of adiposity (ΔHbA(1c): -0.26% [95% CI -0.5 to -0.01] and -0.26% [-0.45 to -0.08]; Δwaist circumference: -2.6 cm [-3.7 to -1.5] and -1.8 cm [-2.6 to -1.0]; Δbody fat: -1.07% [-1.5 to -0.62] and -0.75% [-1.09 to -0.41]). No significant differences were observed in the degree of change of these metabolic parameters between fitness responders and nonresponders. Control group participants had no significant changes in any of these metabolic parameters.

conclusionsET is associated with significant improvements in metabolic parameters irrespective of improvement in cardiorespiratory fitness.

Indexed as

AdiposityDiabetes Mellitus, Type 2ExerciseExercise TestFemaleGlycated HemoglobinHealth StatusHumansMaleMiddle AgedOxygen ConsumptionPhysical FitnessResistance TrainingGlycated Hemoglobin

Identifiers

PMID26084342
PMCPMC4512133

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.