ArticleRadiation protection dosimetry2016
Effects of ionising radiation on micronucleus formation and chromosomal aberrations in Chinese radiation workers.
Article in Radiation protection dosimetry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Biomarkers of Genotoxicity in Medical Workers Exposed to Low-Dose Ionizing Radiation: Systematic Review and Meta-Analyses.International journal of molecular sciences · 2021Pooled it
- Microfluidic Isolation of Aptamers for Intracellular Measurement of Radio-Responsive Proteins.Radiation (Multidisciplinary Digital Publishing Institute) · 2025Article
- Preliminary Study of Spontaneous Micronuclei and Hematology Profile of Workers Exposed to Low-Dose Radiation.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Microfluidic measurement of intracellular mRNA with a molecular beacon probe towards point-of-care radiation triage.Sensors & diagnostics · 2024Article
- The Long-Term Impact of Ionizing Radiation on DNA Damage in Patients Undergoing Multiple Cardiac Catheterizations.Cardiovascular toxicology · 2023Article
- Evaluation of micronuclei and antioxidant status in hospital radiation workers occupationally exposed to low-dose ionizing radiation.BMC health services research · 2023Article
- The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radiation.International journal of environmental research and public health · 2021Article
- The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology.Frontiers in public health · 2021Article
- Evaluation of micronuclei in oral mucosa of individuals exposed to ionizing radiation: a pilot study from Celaya, México.Central Asian journal of global health · 2019Article
- Analysis of copy number variations induced by ultrashort electron beam radiation in human leukocytes in vitro.Molecular cytogenetics · 2019Article
- Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures.Environmental health : a global access science source · 2017Article
- Analysis of Red Blood Cells and their Components in Medical Workers with Occupational Exposure to Low-Dose Ionizing Radiation.Dose-response : a publication of International Hormesis SocietyArticle
- Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study is aimed to investigate the effects of ionising radiation (IR) on micronuclei (MN) formation and chromosome aberrations (CAs) in Chinese radiation workers. The study was conducted using peripheral blood lymphocytes from 1392 radiation workers from Public Hospitals of the city of Tangshan (the exposed group), and 143 healthy individuals as the control group. Fluorescence in situ hybridisation (FISH) was used to detect the unstable and stable nuclear CAs on metaphase. The MN assay was performed using the cytochalasin B method for cytokinesis-block. The MN and CA frequencies were significantly higher in the exposed group than in healthy controls (both p < 0.001). Examination of the incidence rates of MN and CA showed an increasing trend among workers in some occupations compared with the others (all p < 0.05). There were also significant differences in MN and CA rates among workers with different exposure times (all p < 0.05). Stable CA rates demonstrated an increased trend among workers with different exposure times (all p < 0.05), while no significance of unstable CA rates was found among workers with different exposure times (all p < 0.05). Importantly, the frequencies of CA and MN increased among different cumulative radiation dose groups (all p < 0.05). Correlation analysis showed that the frequencies of MN and CA were positively associated with the cumulative radiation dose. Long-term exposure to IR may have harmful effects on the health of radiation workers. The data obtained here show an increased risk of genetic instability that correlated with occupation, exposure time and equivalent dose among Chinese radiation workers.
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