ReviewHypertension research : official journal of the Japanese Society of Hypertension2015
Factors associated with a vicious cycle involving a low nephron number, hypertension and chronic kidney disease.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β-Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil-SR Trandolapril Study) Trials.Journal of the American Heart Association · 2017Trial
- Low Nephron Number and Kidney Disease.International journal of molecular sciences · 2026Review
- Sex and Gender Differences in Chronic Kidney Disease-Explained by the Brenner-Luyckx Concept of Hyperfiltration.Journal of clinical medicine · 2026Review
- Multiscale segmentation using hierarchical phase-contrast tomography and deep learning.PLoS computational biology · 2026Article
- Nephron number variability in Japanese subjects: an autopsy-based study and its implications for chronic kidney disease: clinical scientist award address 2024.Clinical and experimental nephrology · 2025Review
- Estimating Number of Nephrons in Living Pediatric Patients Using Nephrectomy Specimens.Kidney international reports · 2025Article
- Epigenetics of Hypertensive Nephropathy.Biomedicines · 2024Review
- Underlying Mechanisms and Treatment of Hypertension in Glomerular Diseases.Current hypertension reports · 2024Review
- Nutrition and Developmental Origins of Kidney Disease.Nutrients · 2023Review
- Nephrons, podocytes and chronic kidney disease: Strategic antihypertensive therapy for renoprotection.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Impact of early life development on later onset chronic kidney disease and hypertension and the role of evolutionary trade-offs.Experimental physiology · 2022Review
- Glomerular Biomechanical Stress and Lipid Mediators during Cellular Changes Leading to Chronic Kidney Disease.Biomedicines · 2022Review
- Metabolic risks in living kidney donors in South Korea.Kidney research and clinical practice · 2021Article
- A disturbance beyond the barrier-chronic kidney disease allows angiotensinogen invasion.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Outcomes of Hypertensive Kidney Donors Using Current and Past Hypertension Definitions.Kidney international reports · 2021Article
- Ouabain Protects Nephrogenesis in Rats Experiencing Intrauterine Growth Restriction and Partially Restores Renal Function in Adulthood.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Low birth weight trends: possible impacts on the prevalences of hypertension and chronic kidney disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Hypertension after kidney donation: Incidence, predictors, and correlates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- New insights on glomerular hyperfiltration: a Japanese autopsy study.JCI insight · 2017Article
- Adherence to the Mediterranean diet is associated with reduced risk of incident chronic kidney diseases among Tehranian adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that there is substantial variation in the nephron number between individuals. Previous studies using autopsy kidneys have demonstrated that a low nephron number, in relation to a low birth weight, may result in hypertension (HTN) and/or chronic kidney disease (CKD). However, recent studies have revealed that the association between a low nephron number and HTN is not a universal finding. This observation indicates that a low nephron number is unlikely to be the sole factor contributing to an elevated blood pressure. In addition to the nephron number, various genetic and congenital factors may contribute to increased susceptibility to HTN and/or CKD in a complex manner. Acquired factors, including aging, obesity and related metabolic abnormalities, and various causes of renal injury, may additionally promote further nephron loss. Such a vicious cycle may induce HTN and/or CKD via the common mechanisms of renal hemodynamic maladaptation.
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Registered trials
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