Evidence map›Paper›PMID 26084258›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Low vitamin D levels have become less common in primary hyperparathyroidism.

M D Walker, E Cong, J A Lee, A Kepley, C Zhang, D J McMahon, J P Bilezikian, S J Silverberg

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Primary Hyperparathyroidism.The Journal of clinical endocrinology and metabolism · 2018
    Review
  5. Article
  6. Article
  7. Article
  8. Primary hyperparathyroidism.Nature reviews. Endocrinology · 2018
    Review
  9. Article
  10. Effect of concomitant vitamin D deficiency or insufficiency on lumbar spine volumetric bone mineral density and trabecular bone score in primary hyperparathyroidism.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
  11. Article
  12. Article
  13. Article
  14. Hypercalcemia in the Presence of an Ectopic Mediastinal Mass.Journal of primary care & community health
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

M D WalkerDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA. mad2037@columbia.edu.
E CongDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
J A LeeDepartment of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
A KepleyDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
C ZhangDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
D J McMahonDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
J P BilezikianDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
S J SilverbergDepartment of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, PH 8 West - 864, New York, NY, 10032, USA.
Columbia University · US

Funding

PRIMARY HYPERPARATHYROIDISMR01DK032333 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BILEZIKIAN, JOHN P · 1986 to 2018
$9.6M
Vitamin D Deficiency in Primary HyperparathyroidismR01DK084986 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2010 to 2014
$3.0M
Non-Classical Manifestations of Primary HyperparathyroidismK24DK074457 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SILVERBERG, SHONNI J · 2006 to 2016
$1.7M
NIDDK NIH HHS K24 DK074457NIDDK NIH HHS R01 DK032333NIDDK NIH HHS R01 DK084986NIDDK NIH HHS R01DK084986PHS HHS R01 32333
6 · The paper itself

Abstract

unlabelledWe compared temporal trends in serum 25-hydroxyvitamin D and parathyroid hormone (PTH) in two primary hyperparathyroidism (PHPT) cohorts recruited 20 years apart. The prevalence of 25-hydroxyvitamin D levels <20 and <30 ng/mL declined by 30-50 %, respectively, and was accompanied by lower PTH. In the older cohort, higher PTH may be due to lower 25-hydroxyvitamin D.

introductionVitamin D deficiency may exacerbate PHPT. Whether there have been temporal trends in 25-hydroxyvitamin D (25OHD) levels in PHPT is unclear. The prevalence of low vitamin D levels (25OHD <20 and <30 ng/mL) and associated biochemical and bone mineral density (BMD) profiles were assessed in two PHPT cohorts recruited over 20 years apart.

methodsThis is a cross-sectional comparison of serum 25OHD levels, calciotropic hormones, and BMD between two PHPT cohorts recruited at the same hospital: the "old" (N = 103) and "new" (N = 100) cohorts were enrolled between 1984 and 1991 and between 2010 and 2014, respectively.

resultsMean 25OHD levels were 26 % higher in the new cohort (23 ± 10 vs. 29 ± 10 ng/mL, p < 0.0001). Levels of 25OHD <20 and <30 ng/mL declined from 46 and 82 %, respectively, to 19 and 54 % (both p < 0.0001). Supplemental vitamin D use was common in the new (64 %) but not the old cohort (0 %). The new cohort demonstrated 33 % lower serum PTH levels (p < 0.0001). Neither serum nor urine calcium differed. BMD was higher in the new cohort at all skeletal sites (all p < 0.001).

conclusionWith the rise in vitamin D supplementation over the last two decades, low 25OHD levels are no longer common in PHPT patients in the New York area. Those with 25OHD <20 and <30 ng/mL have declined by over 50 and 30 %, respectively. The lower mean PTH levels in the new cohort are most likely accounted for by higher vitamin D intake. Whether improved vitamin D status also underlies the relatively higher BMD in the more vitamin D replete cohort of PHPT patients is unknown.

Indexed as

AdultAgedBone DensityCross-Sectional StudiesDrug UtilizationFemaleHumansHyperparathyroidism, PrimaryMaleMiddle AgedNew YorkParathyroid HormoneVitamin DVitamin D Deficiency25-hydroxyvitamin DParathyroid HormoneVitamin DPrevalencePrimary hyperparathyroidismVitamin D deficiency

Identifiers

PMID26084258
PMCPMC4793903
OpenAlexW604196621

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.