ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.
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Who cites it
93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 162 citations in OpenAlex.
- Psychological interventions for interoception in mental health disorders: A systematic review of randomized-controlled trials.Psychiatry and clinical neurosciences · 2023Pooled it
- An interoceptive model of bulimia nervosa: A neurobiological systematic review.Journal of psychiatric research · 2017Pooled it
- General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation.Translational psychiatry · 2024Trial
- Trial
- Toward an Embodied Medicine: A Portable Device with Programmable Interoceptive Stimulation for Heart Rate Variability Enhancement.Sensors (Basel, Switzerland) · 2018Trial
- Regional gray matter alterations in anorexia nervosa: implications for subtype heterogeneity and clinical severity.Molecular psychiatry · 2026Article
- Real-Time Cardiac Biofeedback Intervention: Experiences of Patient and Public Involvement in a Randomized Controlled Trial.Journal of participatory medicine · 2026Article
- Self-reported interoceptive sensibility across eating disorder symptoms: associations with sociodemographic factors.Journal of eating disorders · 2026Article
- Cariprazine as a candidate for drug repurposing in anorexia nervosa: a mechanistic hypothesis grounded in neuroimaging evidence.Frontiers in pharmacology · 2026Article
- Interoceptive mechanisms of a mobile heart rate variability biofeedback app for eating disorder symptoms: Proof-of-concept findings.Eating behaviors · 2026Article
- Central autonomic network-heart interplay in anorexia nervosa. A cross-spectral dynamic causal modeling study.NeuroImage. Clinical · 2026Article
- Lesions involving the insula are associated with reduced appetite and weight loss.Brain communications · 2026Article
- Interoceptive profiles of eating and weight disorders.Scientific reports · 2025Article
- The relationship between interoception of breathing, anxiety, and resting-state functional connectivity in the brain.Cognitive, affective & behavioral neuroscience · 2025Article
- Sex difference in neural substrates linking negative body image and disordered eating behaviors.Brain structure & function · 2025Article
- Evidence of Altered Biobehavioral Threat Processes in Adolescents With Eating Disorders: A Scoping Review.The International journal of eating disorders · 2025Article
- Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa.The International journal of eating disorders · 2025Article
- Body Mass Index Impacts on Gray Matter Volume in Developmental Restrictive Anorexia Nervosa: A Voxel-Based Morphometry Study.Nutrients · 2025Article
- The Interplay Between Psychological and Neurobiological Predictors of Weight Regain: A Narrative Review.Nutrients · 2025Review
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Anorexia nervosa (AN) is a devastating psychiatric illness that is associated with significant morbidity and mortality. Aberrant visceral interoceptive processing within the insula has been hypothesized to be an important mechanism in AN's pathophysiology due to the theoretical link between interoception and emotional experience. We therefore utilized functional magnetic resonance imaging (fMRI) to examine whether altered insula functioning underlies visceral interoception in AN. Fifteen females with restricting-type AN and 15 healthy control females underwent fMRI while performing an interoceptive attention task during which they focused on sensations in their heart, stomach, and bladder. Participants also performed an anxious rumination task while in the scanner. AN participants were weight-restored and free of psychotropic medications. Two distinct regions of the insula-anterior insula and dorsal mid-insula-exhibited a significant (p<0.05) interaction between group and interoceptive modality. The post hoc analyses revealed that in the dorsal mid-insula the interaction was driven by group differences during stomach interoception (p=0.002, Bonferroni corrected), whereas in the anterior insula the interaction was driven by group differences during heart interoception (p=0.03, Bonferroni corrected). In addition, individuals with AN displayed increased activation during anxious rumination in the dorsal mid-insula, and activation in this region during stomach interoception was correlated with measures of anxiety and psychopathology. This relationship between altered visceral interoception and clinical symptoms in AN suggests an important mechanism for the disorder. Additional research is needed to examine whether interventions targeting visceral interoception may increase the efficacy of treatments for AN.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.