Evidence map›Paper›PMID 26084025›Full record

ArticleImmunity2015

Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors.

Desheng Hu, Sarajo K Mohanta, Changjun Yin, Li Peng, Zhe Ma, Prasad Srikakulapu, Gianluca Grassia, Neil MacRitchie, Gary Dever, Peter Gordon and 15 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 1 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 1 synthesis or guideline pooled it, 210 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  6. Review
  7. CD8Nature reviews. Cardiology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. ApoB-specific CD4Frontiers in immunology · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 6 countries.

Desheng HuInstitute of Molecular Immunology, Helmholtz Zentrum München, Marchioninistrasse 25, 81377 Munich, Germany; Leibniz Institute for Age Research, Fritz Lipmann-Institute, 07745 Jena, Germany.
Sarajo K MohantaInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany.
Changjun YinInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany.
Li PengLeibniz Institute for Age Research, Fritz Lipmann-Institute, 07745 Jena, Germany; Department of Traditional Chinese Medicine, Medical College of Xiamen University, Xiamen University, 361102 Xiamen, P.R. China.
Zhe MaInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany.
Prasad SrikakulapuLeibniz Institute for Age Research, Fritz Lipmann-Institute, 07745 Jena, Germany; Cardiovascular Research Center (CVRC), University of Virginia, 415 Lane Rd, Post Box 801394, Charlottesville, VA 22908, USA.
Gianluca GrassiaCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Neil MacRitchieCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Gary DeverCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Peter GordonCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK; Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Francis L BurtonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, G12 8TA, UK.
Armando IalentiDepartment of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Suleman R SabirCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Iain B McInnesCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
James M BrewerCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Paul GarsideCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
Christian WeberInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany; DZHK, German Center for Cardiovascular Research, Munich Heart Alliance, Pettenkoferstrasse 9, 80336 Munich, Germany; and Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands.
Thomas LehmannInstitute for Medical Statistics, University of Jena, Jena University Hospital, 07743 Jena, Germany.
Daniel TeupserDepartment for Laboratory Medicine, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany.
Livia HabenichtInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany; II. Medizinische Klinik und Poliklinik; Technische Universität Muenchen, Klinikum rechts der Isar, Ismaningerstrasse 22, 81675 Munich, Germany.
Michael BeerDepartment for Information Technology, University of Jena, Jena University Hospital, 07743 Jena, Germany.
Rolf GrabnerLeibniz Institute for Age Research, Fritz Lipmann-Institute, 07745 Jena, Germany.
Pasquale MaffiaCentre for Immunobiology, Institute of Infection, Immunity & Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
Falk WeihLeibniz Institute for Age Research, Fritz Lipmann-Institute, 07745 Jena, Germany.
Andreas J R HabenichtInstitute for Cardiovascular Prevention, Ludwig-Maximilians University, Pettenkoferstrasse 9, 80336 Munich, Germany. Electronic address: andreas.habenicht@med.uni-muenchen.de.
University of Glasgow · GBLudwig-Maximilians-Universität München · DELeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEJena University Hospital · DEGerman Centre for Cardiovascular Research · DEHelmholtz Zentrum München · DEKlinik und Poliklinik für Psychosomatische Medizin und Psychotherapie · DEUniversity of Naples Federico II · ITUniversity of Strathclyde · GBUniversity of Virginia · US

Funding

British Heart Foundation PG/06/083/21198British Heart Foundation PG/12/81/29897European Research Council 249929Wellcome Trust 104111
6 · The paper itself

Abstract

Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe(-/-) mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4(+) T cells, generated CD4(+), CD8(+), T regulatory (Treg) effector and central memory cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells. Meanwhile, vascular smooth muscle cell lymphotoxin β receptors (VSMC-LTβRs) protected against atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTβRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbated in Apoe(-/-)Ltbr(-/-) and to a similar extent in aged Apoe(-/-)Ltbr(fl/fl)Tagln-cre mice. These data support the conclusion that the immune system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTβRs participate in atherosclerosis protection via ATLOs.

Indexed as

AdventitiaAgingAnimalsAortaApolipoproteins EAtherosclerosisCell DifferentiationCell MovementCells, CulturedChoristomaImmunologic MemoryLymphocyte ActivationLymphoid TissueLymphotoxin beta ReceptorMiceMice, Inbred C57BLApolipoproteins ELymphotoxin beta ReceptorMicrofilament ProteinsMuscle Proteinstransgelin

Identifiers

PMID26084025
PMCPMC4678289
OpenAlexW1861425906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.