ArticleBiophysical journal2015
Direct Cytoskeleton Forces Cause Membrane Softening in Red Blood Cells.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 93 citations in OpenAlex.
- Computational Microscopy Reveals Compound-Specific Flickering Phenotypes of Red Blood Cells Under Flavonoid Exposure.Membranes · 2026Article
- Active Force Dynamics in Red Blood Cells Under Non-Invasive Optical Tweezers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stochastic motility energetics reveals cooperative bacterial swarming in optical tweezers.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanical adaptivity of red blood cell flickering to extrinsic membrane stiffening by the solid-like biosurfactant β-Aescin.Biophysical journal · 2025Article
- Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity.Nature communications · 2025Article
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- Active membrane deformations of a minimal synthetic cell.Nature physics · 2025Article
- Red blood cell flickering activity locally controlled by holographic optical tweezers.iScience · 2024Article
- Viscoelastic phenotyping of red blood cells.Biophysical journal · 2024Article
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- Measuring sub-nanometer undulations at microsecond temporal resolution with metal- and graphene-induced energy transfer spectroscopy.Nature communications · 2024Article
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- A bending rigidity parameter for stress granule condensates.Science advances · 2023Article
- Contraction of the rigor actomyosin complex drives bulk hemoglobin expulsion from hemolyzing erythrocytes.Biomechanics and modeling in mechanobiology · 2023Article
- Erythroid SLC7A5/SLC3A2 amino acid carrier controls red blood cell size and maturation.iScience · 2023Article
- RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.Trends in parasitology · 2022Review
- Membrane rigidity regulates E. coli proliferation rates.Scientific reports · 2022Article
- Interplay of receptor-ligand binding and lipid domain formation during cell adhesion.Frontiers in molecular biosciences · 2022Review
- Structural Configuration of Blood Cell Membranes Determines Their Nonlinear Deformation Properties.BioMed research international · 2022Article
- On the Role of Curved Membrane Nanodomains, and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding.International journal of molecular sciences · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythrocytes are flexible cells specialized in the systemic transport of oxygen in vertebrates. This physiological function is connected to their outstanding ability to deform in passing through narrow capillaries. In recent years, there has been an influx of experimental evidence of enhanced cell-shape fluctuations related to metabolically driven activity of the erythroid membrane skeleton. However, no direct observation of the active cytoskeleton forces has yet been reported to our knowledge. Here, we show experimental evidence of the presence of temporally correlated forces superposed over the thermal fluctuations of the erythrocyte membrane. These forces are ATP-dependent and drive enhanced flickering motions in human erythrocytes. Theoretical analyses provide support for a direct force exerted on the membrane by the cytoskeleton nodes as pulses of well-defined average duration. In addition, such metabolically regulated active forces cause global membrane softening, a mechanical attribute related to the functional erythroid deformability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.