ArticleBiophysical journal2015
2-Hydroxy Fatty Acid Enantiomers of Gb3 Impact Shiga Toxin Binding and Membrane Organization.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells.Cellular and molecular life sciences : CMLS · 2022Article
- Chemically synthesized GbEuropean biophysics journal : EBJ · 2021Review
- Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3.Frontiers in molecular biosciences · 2021Review
- Synthesis of GbAngewandte Chemie (International ed. in English) · 2019Article
- Glycan-decorated protocells: novel features for rebuilding cellular processes.Interface focus · 2019Review
- Lipid self-assembly and lectin-induced reorganization of the plasma membrane.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.Scientific reports · 2018Article
- Shiga Toxin Glycosphingolipid Receptors in Human Caco-2 and HCT-8 Colon Epithelial Cell Lines.Toxins · 2017Article
- Mode of Ezrin-Membrane Interaction as a Function of PIP2 Binding and Pseudophosphorylation.Biophysical journal · 2016Article
- Benzothiadiazole oligoene fatty acids: fluorescent dyes with large Stokes shifts.Beilstein journal of organic chemistry · 2016Article
- Specificity of Collybistin-Phosphoinositide Interactions: IMPACT OF THE INDIVIDUAL PROTEIN DOMAINS.The Journal of biological chemistry · 2016Article
- Lipid Chirality Revisited: A Change in Lipid Configuration Transforms Membrane-Bound Protein Domains.Biophysical journal · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shiga toxin subunit B (STxB) binding to its cellular receptor Gb3 leads to the formation of protein-lipid clusters and bending of the membrane. A newly developed synthetic route allowed synthesizing the biologically most relevant Gb3-C24:1 2OH species with both, the natural (Gb3-R) as well as the unnatural (Gb3-S) configuration of the 2OH group. The derivatives bind STxB with identical nanomolar affinity, while the propensity to induce membrane tubules in giant unilamellar vesicles is more pronounced for Gb3-S. Fluorescence and atomic force microscopy images of phase-separated supported membranes revealed differences in the lateral organization of the protein on the membrane. Gb3-R favorably induces large and tightly packed protein clusters, while a lower protein density is found on Gb3-S doped membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.