ArticleBiophysical journal2015
Dynamically Driven Protein Allostery Exhibits Disparate Responses for Fast and Slow Motions.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Evolving Landscape of Protein Allostery: From Computational and Experimental Perspectives.Journal of molecular biology · 2025Review
- Identification and understanding of allostery hotspots in proteins: Integration of deep mutational scanning and multi-faceted computational analyses.Journal of molecular biology · 2025Review
- Drug resistance and tumor heterogeneity: cells and ensembles.Biophysical reviews · 2025Review
- Calculation of centralities in protein kinase A.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Coarse-graining protein structures into their dynamic communities with DCI, a dynamic community identifier.Bioinformatics (Oxford, England) · 2022Article
- Hinge-Shift Mechanism Modulates Allosteric Regulations in Human Pin1.The journal of physical chemistry. B · 2018Article
- Measuring Entropy in Molecular Recognition by Proteins.Annual review of biophysics · 2018Review
- Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains.The journal of physical chemistry. B · 2017Article
- The Exact Nuclear Overhauser Enhancement: Recent Advances.Molecules (Basel, Switzerland) · 2017Review
- Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia.The Journal of biological chemistry · 2017Article
- Article
- Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism.eLife · 2016Article
- Protein Allostery and Conformational Dynamics.Chemical reviews · 2016Review
- Protein Ensembles: How Does Nature Harness Thermodynamic Fluctuations for Life? The Diverse Functional Roles of Conformational Ensembles in the Cell.Chemical reviews · 2016Review
- Allosteric Communication across STAT3 Domains Associated with STAT3 Function and Disease-Causing Mutation.Journal of molecular biology · 2016Article
- Disorder-to-Order Transition of an Active-Site Loop Mediates the Allosteric Activation of Sortase A.Biophysical journal · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
There is considerable interest in the dynamic aspect of allosteric action, and in a growing list of proteins allostery has been characterized as being mediated predominantly by a change in dynamics, not a transition in conformation. For considering conformational dynamics, a protein molecule can be simplified into a number of relatively rigid microdomains connected by joints, corresponding to, e.g., communities and edges from a community network analysis. Binding of an allosteric activator strengthens intermicrodomain coupling, thereby quenching fast (e.g., picosecond to nanosecond) local motions but initiating slow (e.g., microsecond to millisecond), cross-microdomain correlated motions that are potentially of functional importance. This scenario explains allosteric effects observed in many unrelated proteins.
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