Evidence map›Paper›PMID 26083914›Full record

ArticleBiophysical journal2015

Retinal Flip in Rhodopsin Activation?

Jun Feng, Michael F Brown, Blake Mertz

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Hydration-mediated G-protein-coupled receptor activation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  2. Review
  3. Review
  4. Retinal Flips the Script.Biophysical journal · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jun FengThe C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia.
Michael F BrownDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona; Department of Physics, University of Arizona, Tucson, Arizona.
Blake MertzThe C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia. Electronic address: blake.mertz@mail.wvu.edu.

Funding

MEMBRANE BASIS OF VISUAL EXCITATIONR01EY012049 · NEI · UNIVERSITY OF ARIZONA · PI BROWN, MICHAEL F · 1998 to 2012
$3.3M
MEMBRANE BASIS OF VISUAL EXCITATIONR01EY026041 · NEI · UNIVERSITY OF ARIZONA · PI BROWN, MICHAEL F · 2016 to 2018
$1.1M
NEI NIH HHS R01 EY012049NEI NIH HHS R01 EY026041
6 · The paper itself

Abstract

Rhodopsin is a well-characterized structural model of a G protein-coupled receptor. Photoisomerization of the covalently bound retinal triggers activation. Surprisingly, the x-ray crystal structure of the active Meta-II state has a 180° rotation about the long-axis of the retinal polyene chain. Unbiased microsecond-timescale all-atom molecular dynamics simulations show that the retinal cofactor can flip back to the orientation observed in the inactive state of rhodopsin under conditions favoring the Meta-I state. Our results provide, to our knowledge, the first evidence from molecular dynamics simulations showing how rotation of the retinal ligand within its binding pocket can occur in the activation mechanism of rhodopsin.

Indexed as

Molecular Dynamics SimulationAmino Acid SequenceLipid BilayersMolecular Sequence DataRhodopsinRotationLipid BilayersRhodopsin

Identifiers

PMID26083914
PMCPMC4472225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.