ArticleMedicine and science in sports and exercise2015
Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study.
Article in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of the Association Between Muscular Fitness and Telomere Length Across the Adult Lifespan.Frontiers in physiology · 2021Pooled it
- Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.Journal of hematology & oncology · 2025Review
- Mediation role of telomere length in the relationship between physical activity and PhenoAge: A population-based study.Journal of exercise science and fitness · 2025Article
- Micronutrient intake and telomere length: findings from the UK Biobank.European journal of nutrition · 2024Article
- The association of leukocyte telomere length with exceptional longevity among older women.GeroScience · 2024Article
- Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study.Journal of translational medicine · 2024Article
- Influences of Long-Term Exercise and High-Fat Diet on Age-Related Telomere Shortening in Rats.Cells · 2022Article
- Analysis of Telomere Length and Its Implication in Neurocognitive Functions in Elderly Women.Journal of clinical medicine · 2022Article
- Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care.Nature reviews. Clinical oncology · 2022Review
- Review
- Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies.Journal of clinical medicine · 2021Review
- Telomere length and its relationships with lifestyle and behavioural factors: variations by sex and race/ethnicity.Age and ageing · 2021Article
- Comment on: Non-esterified fatty acids and telomere length in older adults.Metabolism open · 2021Article
- Effect of plasma polyunsaturated fatty acid levels on leukocyte telomere lengths in the Singaporean Chinese population.Nutrition journal · 2020Article
- Telomere shortening is associated with poor physical performance in knee osteoarthritis.Biomedical reports · 2020Article
- Review
- How Does Obesity and Physical Activity Affect Aging?: Focused on Telomere as a Biomarker of Aging.Journal of obesity & metabolic syndrome · 2019Review
- Why are there associations between telomere length and behaviour?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Telomeres, Aging and Exercise: Guilty by Association?International journal of molecular sciences · 2017Review
- Association of Accelerometer-Measured Physical Activity With Leukocyte Telomere Length Among Older Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
introductionThe influence of physical activity (PA) and physical fitness (PF) at older ages on changes in telomere length (TL)--repetitive DNA sequences that may mark biologic aging--is not well-established. Few prior studies (mainly cross-sectional) have been conducted in older adults, and few studies have evaluated PF.
methodsWe investigated cross-sectional and prospective associations of PA and PF with leukocyte TL among 582 older adults (mean ± SD age, 73 ± 5 yr at baseline) in the Cardiovascular Health Study, with serial TL measures and PA and PF assessed multiple times. Cross-sectional associations were assessed using multivariable repeated-measures regression, in which cumulatively averaged PA and PF measures were related to TL. Longitudinal analyses assessed cumulatively averaged PA and PF against later changes in TL, and changes in cumulatively averaged PA and PF against changes in TL.
resultsCross-sectionally, greater walking distance and chair test performance, but not other PA and PF measures, were each associated with longer TL (P trend = 0.007 and 0.04, respectively). In longitudinal analyses, no significant associations of baseline PA and PF with change in TL were observed. In contrast, changes in leisure-time activity and chair test performance were each inversely associated with changes in TL.
conclusionsCross-sectional analyses suggest that greater PA and PF are associated with longer TL. Prospective analyses show that changes in PA and PF are associated with differences in changes in TL. Even later in life, changes in certain PA and PF measures are associated with changes in TL, suggesting that leisure-time activity and fitness could reduce leukocyte telomere attrition among older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.