ArticleMedicine and science in sports and exercise2015
Cerebral/Peripheral Vascular Reactivity and Neurocognition in Middle-Age Athletes.
Article in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- The Association of Cardiorespiratory Fitness on Memory Function: Systematic Review.Medicina (Kaunas, Lithuania) · 2019Pooled it
- One-year aerobic exercise altered cerebral vasomotor reactivity in mild cognitive impairment.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Aortic stiffness, central pulse pressure and cognitive function following acute resistance exercise.European journal of applied physiology · 2018Trial
- Alcohol consumption after downhill running does not affect muscle recovery but prolongs pain perception in East Asian men.Physical activity and nutrition · 2024Article
- Physical activity and perceived barriers in individuals with moderate-to-severe traumatic brain injury.PM & R : the journal of injury, function, and rehabilitation · 2023Article
- Habitual exercise influences carotid artery strain and strain rate, but not cognitive function in healthy middle-aged females.European journal of applied physiology · 2023Article
- Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- Influence of habitual aerobic and resistance exercise on cerebrovascular reactivity in healthy young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort.Antioxidants (Basel, Switzerland) · 2019Article
- Exercise Improves Vascular Function, but does this Translate to the Brain?Brain plasticity (Amsterdam, Netherlands) · 2018Review
- Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Article
- Association between aerobic fitness and cerebrovascular function with neurocognitive functions in healthy, young adults.Experimental brain research · 2018Article
- Human cerebrovascular function in health and disease: insights from integrative approaches.Journal of physiological anthropology · 2018Review
- NIRS-based cerebrovascular regulation assessment: exercise and cerebrovascular reactivity.Neurophotonics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMidlife vascular disease risk is associated with higher incidence of cognitive impairment in late life. Regular aerobic exercise improves vascular function, which in turn may translate into better cognitive function. The purpose of this study was to determine the associations among cardiorespiratory fitness, cerebral and peripheral vascular reactivity, and cognitive function in sedentary and endurance-trained middle-age adults.
methodsThirty-two endurance-trained and 27 healthy sedentary participants ages 43-65 yr underwent measurements of maximal oxygen uptake (VO2max), neurocognitive assessment, cerebrovascular reactivity to CO2 (CVR), and brachial artery flow-mediated dilation (FMD).
resultsThere were no group differences in age, sex, education level, fasting blood glucose, and blood pressure. Compared with sedentary subjects, endurance-trained athletes demonstrated better cognitive performance on memory (z-score: -0.36 ± 1.11 vs 0.30 ± 0.76, P < 0.01), attention-executive function (z-score: -0.21 ± 0.53 vs 0.18 ± 0.72, P = 0.02), and total cognitive composite scores (z-score: -0.27 ± 0.63 vs 0.23 ± 0.57, P < 0.01). Furthermore, brachial FMD (4.70% ± 2.50% vs 7.13% ± 3.09%, P < 0.01) and CVR (4.19% ± 0.71%·mm Hg⁻¹ vs 4.69% ± 1.06%·mm Hg⁻¹, P = 0.052) were greater in endurance-trained individuals than in the sedentary subjects. Total cognitive composite scores showed a significant positive association with brachial FMD (r = 0.36, P < 0.01) and CVR (r = 0.30, P = 0.03). Finally, when brachial FMD and CVR were entered as covariates, fitness-related group differences in total cognitive composite score were significantly attenuated (all P > 0.05).
conclusionEndurance-trained middle-age adults demonstrated better cognitive performance, which may, at least in part, be mediated by their enhanced vascular function, including cerebral and endothelial-dependent vascular reactivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.