Evidence map›Paper›PMID 26083623›Full record

ArticlePloS one2015

Interaction between Polymorphisms in Pre-MiRNA Genes and Cooking Oil Fume Exposure on the Risk of Lung Cancer in Chinese Non-Smoking Female Population.

Zhihua Yin, Zhigang Cui, Peng Guan, Xuelian Li, Wei Wu, Yangwu Ren, Qincheng He, Baosen Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 10 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 10 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  9. Association Between COX-2 Polymorphisms and Lung Cancer Risk.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  10. Effect ofTechnology in cancer research & treatment
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  18. ModifiedNanomaterials (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
Zhigang CuiChina Medical University, Shenyang 110013, PR China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
Wei WuDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
Qincheng HeDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China.
Baosen ZhouDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang 110013, PR China; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang 110013, PR China.
China Medical University · CNLiaoning University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth genetic polymorphisms and environmental risk factors play important roles in the development of human chronic diseases including lung cancer. This is the first case-control study of interaction between polymorphisms in pre-miRNA genes and cooking oil fume exposure on the risk of lung cancer.

methodsA hospital-based case-control study of 258 cases and 310 controls was conducted. Six polymorphisms in miRNAs were determined by Taqman allelic discrimination method. The gene-environment interactions were assessed on both additive and multiplicative scale. The statistical analyses were performed mostly with SPSS.

resultsThe combination of the risk genotypes of five miRNA SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-608 rs4919510, miR-27a rs895819 and miR-423 rs6505162) with risk factor (cooking oil fume exposure) contributed to a significantly higher risk of lung cancer, and the corresponding ORs (95% confidence intervals) were 1.91(1.04-3.52), 1.94 (1.16-3.25), 2.06 (1.22-3.49), 1.76 (1.03-2.98) and 2.13 (1.29-3.51). The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively). All the measures of biological interaction indicate that there were not indeed biological interactions between the six SNPs of miRNAs and exposure to cooking oil fumes on an additive scale. Logistic models suggested that the gene-environment interactions were not statistically significant on a multiplicative scale.

conclusionsThe interactions between miRNA SNPs and cooking oil fume exposure suggested by ORs of different combination were not statistically significant.

Indexed as

AdenocarcinomaAgedAllelesAsian PeopleCase-Control StudiesChinaCookingDisease SusceptibilityFemaleGasesGenotypeHumansInterviews as TopicLung NeoplasmsMicroRNAsMiddle AgedGasesMicroRNAsOils

Identifiers

PMID26083623
PMCPMC4471348
OpenAlexW2281407764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.