ReviewJournal of neuropathology and experimental neurology2015
Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature.
Review in Journal of neuropathology and experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis.Journal of neuropathology and experimental neurology · 2024Review
- In severe ADNC, hippocampi with comorbid LATE-NC and hippocampal sclerosis have substantially more astrocytosis than those with LATE-NC or hippocampal sclerosis alone.Journal of neuropathology and experimental neurology · 2023Article
- Characterization of hippocampal sclerosis of aging and its association with other neuropathologic changes and cognitive deficits in the oldest-old.Acta neuropathologica · 2023Article
- A novel histological staging of hippocampal sclerosis that is evident in gray matter loss in vivo.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Limbic-Predominant Age-Related TDP-43 Encephalopathy: LATE-Breaking Updates in Clinicopathologic Features and Biomarkers.Current neurology and neuroscience reports · 2022Review
- Limbic-Predominant Age-Related TDP-43 Encephalopathy: Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis.Neurology · 2022Article
- Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study.Acta neuropathologica communications · 2021Article
- Early Detection of Alzheimer's Disease Using Magnetic Resonance Imaging: A Novel Approach Combining Convolutional Neural Networks and Ensemble Learning.Frontiers in neuroscience · 2020Article
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.Brain : a journal of neurology · 2019Article
- Hippocampal Sclerosis, Argyrophilic Grain Disease, and Primary Age-Related Tauopathy.Continuum (Minneapolis, Minn.) · 2019Review
- Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.The Lancet. Neurology · 2018Article
- Combined neuropathological pathways account for age-related risk of dementia.Annals of neurology · 2018Article
- Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population.Brain pathology (Zurich, Switzerland) · 2018Article
- Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi.Brain pathology (Zurich, Switzerland) · 2018Article
- Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases.Brain pathology (Zurich, Switzerland) · 2018Article
- Hippocampal Sclerosis in the Oldest Old: A Finnish Population-Based Study.Journal of Alzheimer's disease : JAD · 2018Article
- The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2018Review
- Hippocampal Sclerosis in Older Patients: Practical Examples and Guidance With a Focus on Cerebral Age-Related TDP-43 With Sclerosis.Archives of pathology & laboratory medicine · 2017Article
- Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2.Neurobiology of aging · 2017Article
- Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal sclerosis of aging (HS-Aging) is a neurodegenerative disease that mimics Alzheimer disease (AD) clinically and has a prevalence rivaling AD in advanced age. Whereas clinical biomarkers are not yet optimized, HS-Aging has distinctive pathological features that distinguish it from other diseases with "hippocampal sclerosis" pathology, such as epilepsy, cerebrovascular perturbations, and frontotemporal lobar degeneration. By definition, HS-Aging brains show neuronal cell loss and gliosis in the hippocampal formation out of proportion to AD-type pathology; it is strongly associated with aberrant TDP-43 pathology and arteriolosclerosis. Here, we describe 2 cases of "segmental" HS-Aging in which "sclerosis" in the hippocampus was evident only in a subset of brain sections by hematoxylin and eosin (H&E) stain. In these cases, TDP-43 pathology was more widespread on immunostained sections than the neuronal cell loss and gliosis seen in H&E stains. The 2 patients were cognitively intact at baseline and were tracked longitudinally over a decade using cognitive studies with at least 1 neuroimaging scan. We discuss the relevant HS-Aging literature, which indicates the need for a clearer consensus-based delineation of "hippocampal sclerosis" and TDP-43 pathologies in aged subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.