ArticleCanadian respiratory journal
A multidimensional approach to the management of severe asthma: Inflammometry, molecular microbiology and bronchial thermoplasty.
Article in Canadian respiratory journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Severe Asthmatic Responses: The Impact of TSLP.International journal of molecular sciences · 2023Review
- Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma.The Journal of allergy and clinical immunology · 2022Article
- Eosinophilia and Response to Bronchial Thermoplasty.American journal of respiratory and critical care medicine · 2021Article
- Targeting NLRP3 Inflammasome Activation in Severe Asthma.Journal of clinical medicine · 2019Review
- Paucigranulocytic asthma: Uncoupling of airway obstruction from inflammation.The Journal of allergy and clinical immunology · 2019Review
- Asthma Endotypes and an Overview of Targeted Therapy for Asthma.Frontiers in medicine · 2017Review
- Sputum colour can identify patients with neutrophilic inflammation in asthma.BMJ open respiratory research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The authors illustrate the merits of identifying the components of diseases (eg, bronchitis and airway hyper-responsiveness) that contribute to exacerbations in the management of a patient with severe asthma. Quantitative cell counts in sputum identified a neutrophilic – as opposed to eosinophilic – bronchitis that enabled a stepwise weaning of prednisone. Molecular microbiology and extended culture methods identified anaerobes and other airway microbiome that helped to guide the use of antibiotics. Further control of asthma was achieved by performing bronchial thermoplasty.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.