ArticleHealth promotion and chronic disease prevention in Canada : research, policy and practice2015
Arsenic exposure and type 2 diabetes: results from the 2007-2009 Canadian Health Measures Survey.
Article in Health promotion and chronic disease prevention in Canada : research, policy and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Maternal Arsenic Exposure and Gestational Diabetes: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Glycemic Changes Related to Arsenic Exposure: An Overview of Animal and Human Studies.Nutrients · 2024Review
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Research progress on arsenic, arsenic-containing medicinal materials, and arsenic-containing preparations: clinical application, pharmacological effects, and toxicity.Frontiers in pharmacology · 2024Review
- Mechanisms Associated with Cognitive and Behavioral Impairment Induced by Arsenic Exposure.Cells · 2023Review
- Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico).Scientific reports · 2023Article
- Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.International journal of environmental research and public health · 2022Article
- Research for type 2 diabetes mellitus in endemic arsenism areas in central China: role of low level of arsenic exposure and KEAP1 rs11545829 polymorphism.Archives of toxicology · 2022Article
- In vitro toxic interaction of arsenic and hyperglycemia in mitochondria: an important implication of increased vulnerability in pre-diabetics.Environmental science and pollution research international · 2022Article
- The Global Burden of Type 2 Diabetes Attributable to Tobacco: A Secondary Analysis From the Global Burden of Disease Study 2019.Frontiers in endocrinology · 2022Article
- Arsenic Exposure, Arsenic Metabolism, and Glycemia: Results from a Clinical Population in New York City.International journal of environmental research and public health · 2021Article
- A case-control study of arsenic exposure with the risk of primary ovarian insufficiency in women.Environmental science and pollution research international · 2020Article
- Arsenic and fasting blood glucose in the context of other drinking water chemicals: a cross-sectional study in Bangladesh.Environmental research · 2019Article
- Low to moderate toenail arsenic levels in young adulthood and incidence of diabetes later in life: findings from the CARDIA Trace Element study.Environmental research · 2019Article
- The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the Strong Heart Family Study.American journal of epidemiology · 2018Article
- Serum folate and cobalamin levels and urinary dimethylarsinic acid in US children and adults.Environmental science and pollution research international · 2018Article
- Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis.Oncotarget · 2017Article
- Association of Low-Moderate Arsenic Exposure and Arsenic Metabolism with Incident Diabetes and Insulin Resistance in the Strong Heart Family Study.Environmental health perspectives · 2017Article
- Smoking and the risk of type 2 diabetes.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Arsenic: The Underrecognized Common Disease-inducing Toxin.Integrative medicine (Encinitas, Calif.) · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInorganic arsenic and its metabolites are considered dangerous to human health. Although several studies have reported associations between low-level arsenic exposure and diabetes mellitus in the United States and Mexico, this association has not been studied in the Canadian population. We evaluated the association between arsenic exposure, as measured by total arsenic concentration in urine, and the prevalence of type 2 diabetes (T2D) in 3151 adult participants in Cycle 1 (2007-2009) of the Canadian Health Measures Survey (CHMS).
methodsAll participants were tested to determine blood glucose and glycated hemoglobin. Urine analysis was also performed to measure total arsenic. In addition, participants answered a detailed questionnaire about their lifestyle and medical history. We assessed the association between urinary arsenic levels and T2D and prediabetes using multivariate logistic regression while adjusting for potential confounders.
resultsTotal urinary arsenic concentration was positively associated with the prevalence of T2D and prediabetes: adjusted odds ratios were 1.81 (95% CI: 1.12-2.95) and 2.04 (95% CI: 1.03-4.05), respectively, when comparing the highest (fourth) urinary arsenic concentration quartile with the lowest (first) quartile. Total urinary arsenic was also associated with glycated hemoglobin levels in people with untreated diabetes.
conclusionWe found significant associations between arsenic exposure and the prevalence of T2D and prediabetes in the Canadian population. Causal inference is limited due to the cross-sectional design of the study and the absence of long-term exposure assessment.
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