Trial reportPloS one2015
Effects of Vaccination with 10-Valent Pneumococcal Non-Typeable Haemophilus influenza Protein D Conjugate Vaccine (PHiD-CV) on the Nasopharyngeal Microbiome of Kenyan Toddlers.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01028326 (Immunogenicity and Reactogenicity of 10-valent Pneumococcal Conjugate Vaccine), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immunogenicity and Reactogenicity of 10-valent Pneumococcal Conjugate Vaccine (PCV10) in Children Aged 12-59 Months
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Exploring the microbial landscape of the nasopharynx in children: a systematic review of studies using next generation sequencing.Frontiers in microbiomes · 2023Pooled it
- Human microbiota research in Africa: a systematic review reveals gaps and priorities for future research.Microbiome · 2021Pooled it
- The association between pneumococcal vaccination, ethnicity, and the nasopharyngeal microbiota of children in Fiji.Microbiome · 2019Trial
- Article
- The upper respiratory tract microbiome of indigenous Orang Asli in north-eastern Peninsular Malaysia.NPJ biofilms and microbiomes · 2021Article
- Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19.American journal of translational research · 2021Review
- Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature.Journal of clinical medicine · 2020Review
- Panel 4: Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures.International journal of pediatric otorhinolaryngology · 2020Review
- 'Candidatus Ornithobacterium hominis': insights gained from draft genomes obtained from nasopharyngeal swabs.Microbial genomics · 2019Article
- [The Microbiome - The Unscheduled Parameter for Future Therapies].Laryngo- rhino- otologie · 2018Review
- A longitudinal study of the infant nasopharyngeal microbiota: The effects of age, illness and antibiotic use in a cohort of South East Asian children.PLoS neglected tropical diseases · 2017Article
- The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana.The Pediatric infectious disease journal · 2017Article
- Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology.Scientific reports · 2017Article
- Article
- An outbreak of pneumococcal meningitis among older children (≥5 years) and adults after the implementation of an infant vaccination programme with the 13-valent pneumococcal conjugate vaccine in Ghana.BMC infectious diseases · 2016Article
- The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx.Microbiome · 2016Article
- Two sampling methods yield distinct microbial signatures in the nasopharynges of asthmatic children.Microbiome · 2016Article
- Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells.Frontiers in cellular and infection microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivePneumococcal conjugate vaccines reduce the prevalence of vaccine serotypes carried in the nasopharynx. Because this could alter carriage of other potential pathogens, we assessed the nasopharyngeal microbiome of children who had been vaccinated with 10-valent pneumococcal non-typeable Haemophilus influenzae protein-D conjugate vaccine (PHiD-CV).
methodsProfiles of the nasopharyngeal microbiota of 60 children aged 12-59 months, who had been randomized to receive 2 doses of PHiD-CV (n=30) or Hepatitis A vaccine (n=30) 60 days apart, were constructed by 16S rRNA gene pyrosequencing of swab specimens collected before vaccination and 180 days after dose 1.
resultsPrior to vaccination, Moraxella catarrhalis (median of 12.3% of sequences/subject), Streptococcus pneumoniae (4.4%) and Corynebacterium spp. (5.6%) were the most abundant nasopharyngeal bacterial species. Vaccination with PHiD-CV did not significantly alter the species composition, abundance, or prevalence of known pathogens. Distinct microbiomes were identified based on the abundances of Streptococcus, Moraxella, and Haemophilus species. These microbiomes shifted in composition over the study period and were independent of age, sex, school attendance, antibiotic exposure, and vaccination.
conclusionsVaccination of children with two doses of PHiD-CV did not significantly alter the nasopharyngeal microbiome. This suggests limited replacement carriage with pathogens other than non-vaccine strains of S. pneumoniae.
trial registrationclinicaltrials.gov NCT01028326.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.