ArticlePloS one2015
Comparison of Various Equations for Estimating GFR in Malawi: How to Determine Renal Function in Resource Limited Settings?
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review.BMJ open · 2018Pooled it
- Chronic kidney disease in the global adult HIV-infected population: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Renal function during tenofovir‑based antiretroviral therapy among people living with HIV in Lilongwe, Malawi: findings from the prospective LighTen cohort study.BMC infectious diseases · 2026Article
- Article
- Framework of Guidelines for Management of CKD in Asia.Kidney international reports · 2024Article
- Article
- Using race in the estimation of glomerular filtration rates: time for a reversal?Current opinion in nephrology and hypertension · 2020Review
- Methods and reporting of kidney function: a systematic review of studies from sub-Saharan Africa.Clinical kidney journal · 2019Article
- Screening for chronic kidney disease in rural Malawi: results from a diabetic clinic.BMC research notes · 2019Article
- Prevalence of impaired renal function among rural and urban populations: findings of a cross-sectional study in Malawi.Wellcome open research · 2019Article
- Monitoring of gentamicin serum concentrations in obstetrics and gynaecology patients in Namibia.International journal of clinical pharmacy · 2018Observational
- Impact of the estimation equation for GFR on population-based prevalence estimates of kidney dysfunction.BMC nephrology · 2017Article
- The global burden of chronic kidney disease: estimates, variability and pitfalls.Nature reviews. Nephrology · 2017Review
- Assessment of renal function in routine care of people living with HIV on ART in a resource-limited setting in urban Zambia.PloS one · 2017Article
- The prevalence of renal impairment in individuals seeking HIV testing in Urban Malawi.BMC nephrology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is a probably underrated public health problem in Sub-Saharan-Africa, in particular in combination with HIV-infection. Knowledge about the CKD prevalence is scarce and in the available literature different methods to classify CKD are used impeding comparison and general prevalence estimates.
methodsThis study assessed different serum-creatinine based equations for glomerular filtration rates (eGFR) and compared them to a cystatin C based equation. The study was conducted in Lilongwe, Malawi enrolling a population of 363 adults of which 32% were HIV-positive.
resultsComparison of formulae based on Bland-Altman-plots and accuracy revealed best performance for the CKD-EPI equation without the correction factor for black Americans. Analyzing the differences between HIV-positive and -negative individuals CKD-EPI systematically overestimated eGFR in comparison to cystatin C and therefore lead to underestimation of CKD in HIV-positives.
conclusionsOur findings underline the importance for standardization of eGFR calculation in a Sub-Saharan African setting, to further investigate the differences with regard to HIV status and to develop potential correction factors as established for age and sex.
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