ArticleJournal of the American Chemical Society2015
Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging.
Article in Journal of the American Chemical Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 99 citations in OpenAlex.
- Polydopamine-Coated Solid Silica Nanoparticles Encapsulating IR-783 Dyes: Synthesis and NIR Fluorescent Cell Imaging.ACS omega · 2024Article
- Near-Infrared-Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Internalization of Pegylated Er:YACS applied nano materials · 2023Article
- Fluorescent and Magnetic Radical Dendrimers as Potential Bimodal Imaging Probes.Pharmaceutics · 2023Article
- Molecular Engineering of Self-Immolative Bioresponsive MR Probes.Journal of the American Chemical Society · 2023Article
- Novel Dual-Mode NIR-II/MRI Nanoprobe Targeting PD-L1 Accurately Evaluates the Efficacy of Immunotherapy for Triple-Negative Breast Cancer.International journal of nanomedicine · 2023Article
- Far-Red Fluorescent Murine Glioma Model for Accurate Assessment of Brain Tumor Progression.Cancers · 2022Article
- Indocyanine-type Infrared-820 Encapsulated Polymeric Nanoparticle-Assisted Photothermal Therapy of Cancer.ACS omega · 2022Article
- Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Recent progress in developing fluorescent probes for imaging cell metabolites.Biomedical materials (Bristol, England) · 2021Review
- Design of pure heterodinuclear lanthanoid cryptate complexes.Chemical science · 2021Article
- Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications.Frontiers in chemistry · 2021Review
- Article
- The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors.Frontiers in oncology · 2021Review
- Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes.Bioconjugate chemistry · 2020Article
- Synthesis and Biological Evaluation of Genistein-IR783 Conjugate: Cancer Cell Targeted Delivery in MCF-7 for Superior Anti-Cancer Therapy.Molecules (Basel, Switzerland) · 2019Article
- RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery.Chemical science · 2019Article
- Fluorescent probes for organelle-targeted bioactive species imaging.Chemical science · 2019Review
- PEG-coated and Gd-loaded fluorescent silica nanoparticles for targeted prostate cancer magnetic resonance imaging and fluorescence imaging.International journal of nanomedicine · 2019Article
- IR-783 Labeling of a Peptide Receptor for 'Turn-On' Fluorescence Based Sensing.Chemosensors (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Multiple imaging modalities are often required for in vivo imaging applications that require both high probe sensitivity and excellent spatial and temporal resolution. In particular, MR and optical imaging are an attractive combination that can be used to determine both molecular and anatomical information. Herein, we describe the synthesis and in vivo testing of two multimeric NIR-MR contrast agents that contain three Gd(III) chelates and an IR-783 dye moiety. One agent contains a PEG linker and the other a short alkyl linker. These agents label cells with extraordinary efficacy and can be detected in vivo using both imaging modalities. Biodistribution of the PEGylated agent shows observable fluorescence in xenograft MCF7 tumors and renal clearance by MR imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.