ArticleBiomatter2015
Small-sized granules of biphasic bone substitutes support fast implant bed vascularization.
Article in Biomatter, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Histomorphometric Evaluation of Socket Preservation Healing Using Xenogeneic Bone Substitute Combined with Statin: A Prospective Split-Mouth Clinical Pilot Study.Acta stomatologica Croatica · 2026Article
- Alveolar Ridge Preservation Revisited: A Multimodal Evaluation of Bone Preservation and Regeneration-Preliminary Findings from a Randomized Controlled Clinical Trial.Bioengineering (Basel, Switzerland) · 2026Article
- A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review.International journal of implant dentistry · 2024Review
- Biphasic bone substitutes coated with PLGA incorporating therapeutic ions SrFrontiers in bioengineering and biotechnology · 2024Article
- Comparison of Particulate, Block and Putty Forms of β-tricalcium Phosphate-Based Synthetic Bone Grafts on Rat Calvarium Model.Journal of maxillofacial and oral surgery · 2023Article
- Analyses of the Cellular Interactions between the Ossification of Collagen-Based Barrier Membranes and the Underlying Bone Defects.International journal of molecular sciences · 2023Article
- Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes.International journal of molecular sciences · 2022Review
- In Vivo Analysis of the Regeneration Capacity and Immune Response to Xenogeneic and Synthetic Bone Substitute Materials.International journal of molecular sciences · 2022Article
- Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study.Antibiotics (Basel, Switzerland) · 2022Article
- In Vivo Biocompatibility Analysis of a Novel Barrier Membrane Based on Bovine Dermis-Derived Collagen for Guided Bone Regeneration (GBR).Membranes · 2022Article
- In Vivo Biocompatibility Investigation of an Injectable Calcium Carbonate (Vaterite) as a Bone Substitute including Compositional Analysis via SEM-EDX Technology.International journal of molecular sciences · 2022Article
- Effect of Photobiomodulation Therapy Associated With Biphasic Phosphate Calcium on Bone Repair: A Histomorphometric Study in Rats.Journal of lasers in medical sciences · 2022Article
- The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes.Materials (Basel, Switzerland) · 2021Article
- Multinucleated Giant Cells Induced by a Silk Fibroin Construct Express Proinflammatory Agents: An Immunohistological Study.Materials (Basel, Switzerland) · 2021Article
- Ex Vivo and In Vivo Analysis of a Novel Porcine Aortic Patch for Vascular Reconstruction.International journal of molecular sciences · 2021Article
- In Vivo Analysis of the Biocompatibility and Bone Healing Capacity of a Novel Bone Grafting Material Combined with Hyaluronic Acid.International journal of molecular sciences · 2021Article
- Exploring the Biomaterial-Induced Secretome: Physical Bone Substitute Characteristics Influence the Cytokine Expression of Macrophages.International journal of molecular sciences · 2021Article
- Article
- Physical characterization of biphasic bioceramic materials with different granulation sizes and their influence on bone repair and inflammation in rat calvaria.Scientific reports · 2021Article
- In Vivo Analysis of the Biocompatibility and Immune Response of Jellyfish Collagen Scaffolds and its Suitability for Bone Regeneration.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the influence of granule size of 2 biphasic bone substitutes (BoneCeramic® 400-700 μm and 500-1000 μm) on the induction of multinucleated giant cells (MNGCs) and implant bed vascularization in a subcutaneous implantation model in rats. Furthermore, degradation mechanisms and particle phagocytosis of both materials were examined by transmission electron microscopy (TEM). Both granule types induced tissue reactions involving primarily mononuclear cells and only small numbers of MNGCs. Higher numbers of MNGCs were detected in the group with small granules starting on day 30, while higher vascularization was observed only at day 10 in this group. TEM analysis revealed that both mono- and multinucleated cells were involved in the phagocytosis of the materials. Additionally, the results allowed recognition of the MNGCs as the foreign body giant cell phenotype. Histomorphometrical analysis of the size of phagocytosed particles showed no differences between the 2 granule types. The results indicate that granule size seems to have impact on early implant bed vascularization and also on the induction of MNGCs in the late phase of the tissue reaction. Furthermore, the results revealed that a synthetic bone substitute material can induce tissue reactions similar to those of some xenogeneic materials, thus pointing to a need to elucidate their "ideal" physical characteristics. The results also show that granule size in the range studied did not alter phagocytosis by mononuclear cells. Finally, the investigation substantiates the differentiation of material-induced MNGCs, which are of the foreign body giant cell type.
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