ArticleNeurophotonics
Route to genetically targeted optical electrophysiology: development and applications of voltage-sensitive fluorescent proteins.
Article in Neurophotonics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecular tools for imaging and recording neuronal activity.Nature chemical biology · 2019Review
- Multimodal Functional Neuroimaging by Simultaneous BOLD fMRI and Fiber-Optic Calcium Recordings and Optogenetic Control.Molecular imaging and biology · 2018Review
- Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship.Neurophotonics · 2017Review
- Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald.Neurophotonics · 2017Review
- Voltage imaging to understand connections and functions of neuronal circuits.Journal of neurophysiology · 2016Review
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Optogenetics enlightens neuroscience drug discovery.Nature reviews. Drug discovery · 2016Review
- Optogenetic Monitoring of Synaptic Activity with Genetically Encoded Voltage Indicators.Frontiers in synaptic neuroscience · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The invention of membrane voltage protein indicators widens the reach of optical voltage imaging in cell physiology, most notably neurophysiology, by enabling membrane voltage recordings from genetically defined cell types in chronic and life-long preparations. While the last years have seen a dramatic improvement in the technical performance of these indicators, concomitant innovations in optogenetics, optical axon tracing, and high-speed digital microscopy are beginning to fulfill the age-old vision of an all-optical analysis of neuronal circuits, reaching beyond the limits of traditional electrode-based recordings. We will present our personal account of the development of protein voltage indicators from the pioneering days to the present state, including their applications in neurophysiology that has inspired our own work for more than a decade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.