ArticleInternational journal of organ transplantation medicine2015
Frequency of Polyomavirus BK Infection in Kidney Transplant Patients Suspected to Nephropathy.
Article in International journal of organ transplantation medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Case Report: Extracorporeal photopheresis for BK virus nephropathy as a novel treatment for high-risk rejection kidney transplant recipient.Frontiers in nephrology · 2025Article
- Extracellular Vesicles: The Future of Diagnosis in Solid Organ Transplantation?International journal of molecular sciences · 2023Review
- BK Virus-Associated Nephropathy after Renal Transplantation.Pathogens (Basel, Switzerland) · 2021Review
- Non-Invasive Diagnosis for Acute Rejection Using Urinary mRNA Signature Reflecting Allograft Status in Kidney Transplantation.Frontiers in immunology · 2021Article
- Exosomal miRNAs: novel players in viral infection.Epigenomics · 2020Review
- Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?Cells · 2019Review
- Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients.PloS one · 2017Article
- Polyomavirus BK Induces Inflammation via Up-regulation of CXCL10 at Translation Levels in Renal Transplant Patients with Nephropathy.Inflammation · 2016Article
- BK Virus and Nephropathy in Kidney Transplant Recipients.International journal of organ transplantation medicine · 2016Article
- BK Viremia among Iranian Renal Transplant Candidates.Iranian journal of pathology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyomavirus BK is a major cause of nephropathy in immunosuppressed transplanted patients. Non-invasive diagnostic protocols such as molecular detection of polyomavirus BK replication are a useful strategy to predict BK virus-associated nephropathy (BKVAN).
objectiveTo determine the prevalence of polyomavirus BK infection among kidney transplant patients suspected to have BKVAN.
methodsIn a cross-sectional study 108 kidney transplanted patients whose laboratory and clinical presentation were in favor of nephropathy between 2010 and 2012, were enrolled for analysis. Polyomavirus BK replication was evaluated in plasma and tissue samples of studied patients using a quantitative real-time PCR. Active cytomegalovirus infection was analyzed in studied patients using antigenemia method. A possible association between polyomavirus BK infection with clinical and laboratory risk factors of BKVAN were evaluated.
resultsThe polyomavirus BK replication was found in 17 (15.7%) of 108 of plasma and 9 (11%) of 82 tissue samples in kidney transplanted patients. Cytomegalovirus co-infection was found in 3 of 17 and 3 of 9 plasma and tissue samples in polyomavirus BK infected patients, respectively. Significant associations were found between polyomavirus BK infection with tubulointerstitial nephritis and acute cellular rejection, as important pathologic findings of BKVAN.
conclusionDiagnosis of single and co-infection of polyomavirus BK infection in plasma samples is a useful assay to evaluate the risk of BKVAN in kidney transplant patients. Established threshold values for studied viral infections have beneficial use in screening of kidney transplant patients at risk of BKVAN, need to confirm and standardized in completed further studies.
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26082831PMC4464281W2203715149What OpenQuestion holds
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