ArticleInternational journal of nanomedicine2015
Mesoporous bioactive glass surface modified poly(lactic-co-glycolic acid) electrospun fibrous scaffold for bone regeneration.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nanoparticle-Enabled Modulation of the Bone Immune Microenvironment for Enhanced Regeneration.Bioengineering (Basel, Switzerland) · 2026Review
- Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering.APL bioengineering · 2023Article
- Enhanced Osteogenic Activity and Bone Repair Ability of PLGA/MBG Scaffolds Doped with ZIF-8 Nanoparticles Loaded with BMP-2.International journal of nanomedicine · 2023Article
- MBG/ PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features.Bioactive materials · 2022Article
- FGF adsorbed mesoporous bioactive glass with larger pores in enhancing bone tissue engineering.Journal of materials science. Materials in medicine · 2019Article
- Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair.International journal of biological sciences · 2019Article
- Enhanced osteoinduction of electrospun scaffolds with assemblies of hematite nanoparticles as a bioactive interface.International journal of nanomedicine · 2019Article
- Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold.Progress in biomaterials · 2018Article
- Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry.International journal of nanomedicine · 2017Article
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Authors and funding
13 authors.
Funding
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Abstract
A mesoporous bioactive glass (MBG) surface modified with poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous scaffold for bone regeneration was prepared by dip-coating a PLGA electrospun fibrous scaffold into MBG precursor solution. Different surface structures and properties were acquired by different coating times. Surface morphology, chemical composition, microstructure, pore size distribution, and hydrophilicity of the PLGA-MBG scaffold were characterized. Results of scanning electron microscopy indicated that MBG surface coating made the scaffold rougher with the increase of MBG content. Scaffolds after MBG modification possessed mesoporous architecture on the surface. The measurements of the water contact angles suggested that the incorporation of MBG into the PLGA scaffold improved the surface hydrophilicity. An energy dispersive spectrometer evidenced that calcium-deficient carbonated hydroxyapatite formed on the PLGA-MBG scaffolds after a 7-day immersion in simulated body fluid. In vitro studies showed that the incorporation of MBG favored cell proliferation and osteogenic differentiation of human mesenchymal stem cells on the PLGA scaffolds. Moreover, the MBG surface-modified PLGA (PLGA-MBG) scaffolds were shown to be capable of providing the improved adsorption/release behaviors of bone morphogenetic protein-2 (BMP-2). It is very significant that PLGA-MBG scaffolds could be effective for BMP-2 delivery and bone regeneration.
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