Evidence map›Paper›PMID 26082557›Full record

ArticleCirculation research2015

MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction.

Yanfei Yang, Hui-Wen Cheng, Yiling Qiu, David Dupee, Madyson Noonan, Yi-Dong Lin, Sudeshna Fisch, Kazumasa Unno, Konstantina-Ioanna Sereti, Ronglih Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 225 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Epigenetic Mechanisms in Heart Diseases.Reviews in cardiovascular medicine · 2025
    Review
  7. Therapeutic Applications of Poly-miRNAs and miRNA Sponges.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Non-Coding RNA-Targeted Therapy: A State-of-the-Art Review.International journal of molecular sciences · 2024
    Review
  17. Unlocking the dark matter: noncoding RNAs and RNA modifications in cardiac aging.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  18. Article
  19. Article
  20. Review

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yanfei YangFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Hui-Wen ChengFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Yiling QiuFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
David DupeeFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Madyson NoonanFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Yi-Dong LinFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Sudeshna FischFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Kazumasa UnnoFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Konstantina-Ioanna SeretiFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.).
Ronglih LiaoFrom the Divisions of Genetics and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (Y.Y., H.-W.C., Y.Q., D.D., M.N., Y.-D.L., S.F., K.U., K.-I.S., R.L.). rliao@rics.bwh.harvard.edu.
Brigham and Women's Hospital · US

Funding

Cardiac MRI-Tractography In Vivo: Integrated Imaging of Structure and FunctionR01HL112831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2013 to 2016
$3.0M
Role of Abcg2/Bcrp1 in Cardiac Side Population CellsR01HL093148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIAO, RONGLIH · 2008 to 2012
$2.1M
NHLBI NIH HHS HL093148NHLBI NIH HHS HL112831NHLBI NIH HHS R01 HL093148NHLBI NIH HHS R01 HL112831
6 · The paper itself

Abstract

rationaleIn response to injury, the rodent heart is capable of virtually full regeneration via cardiomyocyte proliferation early in life. This regenerative capacity, however, is diminished as early as 1 week postnatal and remains lost in adulthood. The mechanisms that dictate postinjury cardiomyocyte proliferation early in life remain unclear.

objectiveTo delineate the role of miR-34a, a regulator of age-associated physiology, in regulating cardiac regeneration secondary to myocardial infarction (MI) in neonatal and adult mouse hearts. METHODS AND

resultsCardiac injury was induced in neonatal and adult hearts through experimental MI via coronary ligation. Adult hearts demonstrated overt cardiac structural and functional remodeling, whereas neonatal hearts maintained full regenerative capacity and cardiomyocyte proliferation and recovered to normal levels within 1-week time. As early as 1 week postnatal, miR-34a expression was found to have increased and was maintained at high levels throughout the lifespan. Intriguingly, 7 days after MI, miR-34a levels further increased in the adult but not neonatal hearts. Delivery of a miR-34a mimic to neonatal hearts prohibited both cardiomyocyte proliferation and subsequent cardiac recovery post MI. Conversely, locked nucleic acid-based anti-miR-34a treatment diminished post-MI miR-34a upregulation in adult hearts and significantly improved post-MI remodeling. In isolated cardiomyocytes, we found that miR-34a directly regulated cell cycle activity and death via modulation of its targets, including Bcl2, Cyclin D1, and Sirt1.

conclusionsmiR-34a is a critical regulator of cardiac repair and regeneration post MI in neonatal hearts. Modulation of miR-34a may be harnessed for cardiac repair in adult myocardium.

Indexed as

AnimalsAnimals, NewbornFemaleHeartMaleMiceMicroRNAsMyocardial InfarctionMyocytes, CardiacPregnancyRegenerationMicroRNAsMIRN34a microRNA, mousecellular proliferationmiR-34a, mousemyocardial infarctionmyocytes, cardiacregeneration

Identifiers

PMID26082557
PMCPMC4769861
OpenAlexW2129319148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.