ArticleAge and ageing2015
Inflammatory and vascular markers and olfactory impairment in older adults.
Article in Age and ageing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults.Scientific reports · 2021Trial
- Integrative genetic analysis reveals new relationships between intraocular pressure, glaucoma, and ischemic stroke risk: a study based on combined SNP-to-gene, Mendelian randomization and pathway investigations.Briefings in bioinformatics · 2025Article
- Aging and chronic inflammation: impacts on olfactory dysfunction-a comprehensive review.Cellular and molecular life sciences : CMLS · 2025Review
- Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults.Journal of the American Heart Association · 2024Article
- Poor olfaction prior to cardiac surgery: Association with cognition, plasma neurofilament light, and post-operative delirium.International journal of geriatric psychiatry · 2024Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
- Potential Role for Diet in Mediating the Association of Olfactory Dysfunction and Cognitive Decline: A Nationally Representative Study.Nutrients · 2023Article
- Factors Associated with Poor Olfaction and Olfactory Decline in Older Adults in the ARIC Neurocognitive Study.Nutrients · 2023Article
- Lifestyle and factors of vascular and metabolic health and inflammation are associated with sensorineural-neurocognitive aging in older adults.Frontiers in epidemiology · 2023Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Environmental Air Pollution and Olfactory Decline in Aging.Environmental health perspectives · 2022Article
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
- Correlates of olfactory impairment in middle-aged non-diabetic Caucasian subjects with stage I-II obesity.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Acute Systemic Experimental Inflammation Does Not Reduce Human Odor Identification Performance.Chemical senses · 2021Article
- Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Prevalence and recovery time of olfactory and gustatory dysfunction in hospitalized patients with COVID‑19 in Wuhan, China.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020Article
- Olfactory Dysfunction in Patients with Ischemic Heart Failure.Acta Cardiologica Sinica · 2020Article
- Mechanisms Linking Olfactory Impairment and Risk of Mortality.Frontiers in neuroscience · 2020Review
- Early Aging Effect on the Function of the Human Central Olfactory System.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundthe incidence of olfactory impairment increases sharply in the eighth and ninth decades of life but the aetiology of age-related olfactory decline is not well understood. Inflammation and atherosclerosis are associated with many age-related conditions and atherosclerosis has been associated with olfactory decline in middle-aged adults.
objectiveto determine if inflammatory markers and atherosclerosis are associated with the development of olfactory impairment in older adults.
designlongitudinal, population-based study. SETTING/
participantsa total of 1,611 participants, aged 53-97 years in the Epidemiology of Hearing Loss Study without olfactory impairment at the 1998-2000 examination and with follow-up at a subsequent examination 5 and/or 10 years later.
methodsthe San Diego Odor Identification Test was used to measure olfaction. High sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor-α were measured in serum and carotid ultrasound images were obtained for the measurement of carotid intima media thickness (IMT) and plaque assessment. Medical history, behavioural and lifestyle information were obtained by interview.
resultsinflammatory markers, IMT and plaque were not associated with the 10-year cumulative incidence of olfactory impairment in adjusted Cox proportional hazard models. Among those <60 years, the mean IMT [hazard ratio (HR) = 4.35, 95% confidence interval (CI) = 1.69-11.21, tertile 3 versus tertile 1] and the number of sites with plaque (HR = 1.56, 95% CI = 1.17-2.08, per site) were associated with an increased risk of developing an olfactory impairment at follow-up.
conclusionsubclinical atherosclerosis at a younger age may be a risk factor for the development of olfactory impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.