ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2015
Fine mapping of Msv1, a major QTL for resistance to Maize Streak Virus leads to development of production markers for breeding pipelines.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Ecology and evolutionary dynamics of the A-strain maize streak virus and the decade-long strategies targeting streak-resistant maize.Virus research · 2026Review
- Development of a Medium-Density Genotyping Platform to Accelerate Genetic Gain in Fresh Edible Maize.Plants (Basel, Switzerland) · 2026Article
- Allelic differences within DNA polymerase delta subunit 1 correlate with geminivirus resistance in diverse plants.G3 (Bethesda, Md.) · 2025Article
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- SeqSNP-based genic markers reveal genetic architecture and candidate genes for low nitrogen tolerance in tropical maize inbred lines.Frontiers in plant science · 2025Article
- Identification of gray leaf spot-resistant donor lines in tropical maize germplasm and their agronomic performance under artificial inoculation.Frontiers in plant science · 2025Article
- Breeding for resistance to maize streak virus: challenges, progress and future directions: a review.Frontiers in plant science · 2025Review
- Approaches and progress in breeding drought-tolerant maize hybrids for tropical lowlands in west and central Africa.The plant genome · 2024Review
- The rising threat of geminiviruses: molecular insights into the disease mechanism and mitigation strategies.Molecular biology reports · 2023Review
- Genome-Wide Association Study for Root Morphology and Phosphorus Acquisition Efficiency in Diverse Maize Panels.International journal of molecular sciences · 2023Article
- Identification and validation of a key genomic region on chromosome 6 for resistance to Fusarium stalk rot in tropical maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Genetic trends in CIMMYT's tropical maize breeding pipelines.Scientific reports · 2022Article
- Low-Density Reference Fingerprinting SNP Dataset of CIMMYT Maize Lines for Quality Control and Genetic Diversity Analyses.Plants (Basel, Switzerland) · 2022Article
- Back to the wild: mining maize (Zea mays L.) disease resistance using advanced breeding tools.Molecular biology reports · 2022Article
- Maize streak virus research in Africa: an end or a crossroad.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Control of Plant Viral Diseases by CRISPR/Cas9: Resistance Mechanisms, Strategies and Challenges in Food Crops.Plants (Basel, Switzerland) · 2021Review
- Genome-wide association studies in tropical maize germplasm reveal novel and known genomic regions for resistance to Northern corn leaf blight.Scientific reports · 2020Article
- Fine mapping and gene cloning in the post-NGS era: advances and prospects.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- An Integrated Molecular and Conventional Breeding Scheme for Enhancing Genetic Gain in Maize in Africa.Frontiers in plant science · 2019Review
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Msv1 , the major QTL for MSV resistance was delimited to an interval of 0.87 cM on chromosome 1 at 87 Mb and production markers with high prediction accuracy were developed. Maize streak virus (MSV) disease is a devastating disease in the Sub-Saharan Africa (SSA), which causes significant yield loss in maize. Resistance to MSV has previously been mapped to a major QTL (Msv1) on chromosome 1 that is germplasm and environment independent and to several minor loci elsewhere in the genome. In this study, Msv1 was fine-mapped through QTL isogenic recombinant strategy using a large F 2 population of CML206 × CML312 to an interval of 0.87 cM on chromosome 1. Genome-wide association study was conducted in the DTMA (Drought Tolerant Maize for Africa)-Association mapping panel with 278 tropical/sub-tropical breeding lines from CIMMYT using the high-density genotyping-by-sequencing (GBS) markers. This study identified 19 SNPs in the region between 82 and 93 Mb on chromosome 1(B73 RefGen_V2) at a P < 1.00E-04, which coincided with the fine-mapped region of Msv1. Haplotype trend regression identified a haplotype block significantly associated with response to MSV. Three SNPs in this haplotype block at 87 Mb on chromosome 1 had an accuracy of 0.94 in predicting the disease reaction in a collection of breeding lines with known responses to MSV infection. In two biparental populations, selection for resistant Msv1 haplotype demonstrated a reduction of 1.03-1.39 units on a rating scale of 1-5, compared to the susceptible haplotype. High-throughput KASP assays have been developed for these three SNPs to enable routine marker screening in the breeding pipeline for MSV resistance.
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