Evidence map›Paper›PMID 26081768›Full record

ArticleHuman genomics2015

Success stories in genomic medicine from resource-limited countries.

Konstantinos Mitropoulos, Hayat Al Jaibeji, Diego A Forero, Paul Laissue, Ambroise Wonkam, Catalina Lopez-Correa, Zahurin Mohamed, Wasun Chantratita, Ming Ta Michael Lee, Adrian Llerena and 3 more

Abstract read
In one paragraph

Article in Human genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Advancing Pharmacogenomics from Single-Gene to Preemptive Testing.Annual review of genomics and human genetics · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Precision Medicine in Control of Visceral Leishmaniasis Caused byFrontiers in cellular and infection microbiology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Konstantinos MitropoulosThe Golden Helix Foundation, London, UK. k.mitropoulos@goldenhelix.org.
Hayat Al JaibejiUniversity of Maastricht, Maastricht, The Netherlands. hayat_aljaibeji@yahoo.com.
Diego A ForeroLaboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia. diego.forero@uan.edu.co.
Paul LaissueUnidad de Genética, Grupo GENIUROS, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia. paul.laissue@urosario.edu.co.
Ambroise WonkamDivision of Human Genetics, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. ambroise.wonkam@uct.ac.za.
Catalina Lopez-CorreaGenome Quebec, Montreal, Canada. clopezcorrea@gmail.com.
Zahurin MohamedDepartment of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. zahurin@ummc.edu.my.
Wasun ChantratitaDepartment of Pathology, Medical Genomic Center, Ramathibodi Hospital, Faculty of Medicine, Mahidol University, Bangkok, Thailand. wasun.cha@mahidol.edu.
Ming Ta Michael LeeLaboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. mikelee@src.riken.jp.
Adrian LlerenaCICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Spain. allerena@unex.es.
Angela BrandUniversity of Maastricht, Maastricht, The Netherlands. a.brand@maastrichtuniversity.nl.
Bassam R AliDepartment of Pathology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates. bassam.ali@uaeu.ac.ae.
George P PatrinosDepartment of Pharmacy, University of Patras School of Health Sciences, Patras, Greece. gpatrinos@upatras.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the translation of genomic discoveries into mainstream medical practice and public health has gained momentum, facilitated by the advent of new technologies. However, there are often major discrepancies in the pace of implementation of genomic medicine between developed and developing/resource-limited countries. The main reason does not only lie in the limitation of resources but also in the slow pace of adoption of the new findings and the poor understanding of the potential that this new discipline offers to rationalize medical diagnosis and treatment. Here, we present and critically discuss examples from the successful implementation of genomic medicine in resource-limited countries, focusing on pharmacogenomics, genome informatics, and public health genomics, emphasizing in the latter case genomic education, stakeholder analysis, and economics in pharmacogenomics. These examples can be considered as model cases and be readily replicated for the wide implementation of pharmacogenomics and genomic medicine in other resource-limited environments.

Indexed as

GenomicsDeveloped CountriesGenome, HumanHumansPharmacogeneticsPublic HealthTranslational Research, Biomedical

Identifiers

PMID26081768
PMCPMC4485996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.