ArticleJournal of applied toxicology : JAT2015
Distribution and biomarker of carbon-14 labeled fullerene C60 ([(14) C(U)]C60 ) in pregnant and lactating rats and their offspring after maternal intravenous exposure.
Article in Journal of applied toxicology : JAT, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies.Particle and fibre toxicology · 2020Pooled it
- Nephrotoxicity Evaluation of Green and Chemically Synthesized Copper Oxide Nanoparticles in Rats: A Biochemical and Genotoxic Approach.Current pharmaceutical design · 2026Article
- In Utero Nano-Titanium Dioxide Exposure Results in Sexually Dimorphic Weight Gain and Cardiovascular Function in Offspring.Cardiovascular toxicology · 2025Article
- Reproductive Toxicity of Nanoparticles: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Determinants and mechanisms of inorganic nanoparticle translocation across mammalian biological barriers.Archives of toxicology · 2023Review
- Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants.Metabolites · 2021Article
- Comparison of silver nanoparticle-induced inflammatory responses between healthy and metabolic syndrome mouse models.Journal of toxicology and environmental health. Part A · 2020Article
- Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD.Reproductive toxicology (Elmsford, N.Y.) · 2018Article
- Engineered nanomaterial applications in perinatal therapeutics.Pharmacological research · 2018Review
- First determination of fullerenes in the Austrian market and environment: quantitative analysis and assessment.Environmental science and pollution research international · 2018Article
- Disposition of intravenously or orally administered silver nanoparticles in pregnant rats and the effect on the biochemical profile in urine.Journal of applied toxicology : JAT · 2017Article
- Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study.Pediatric nephrology (Berlin, Germany) · 2017Article
- Toxicity of Nanoparticles on the Reproductive System in Animal Models: A Review.Frontiers in pharmacology · 2017Review
- Association of urinary metabolites with radiographic progression of knee osteoarthritis in overweight and obese adults: an exploratory study.Osteoarthritis and cartilage · 2016Article
- Microfluidics meets metabolomics to reveal the impact of Campylobacter jejuni infection on biochemical pathways.Biomedical microdevices · 2016Article
- Uterine microvascular sensitivity to nanomaterial inhalation: An in vivo assessment.Toxicology and applied pharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
A comprehensive distribution study was conducted in pregnant and lactating rats exposed to a suspension of uniformly carbon-14 labeled C60 ([(14) C(U)]C60 ). Rats were administered [(14) C(U)]C60 (~0.2 mg [(14) C(U)]C60 kg(-1) body weight) or 5% polyvinylpyrrolidone (PVP)-saline vehicle via a single tail vein injection. Pregnant rats were injected on gestation day (GD) 11 (terminated with fetuses after either 24 h or 8 days), GD15 (terminated after 24 h or 4 days), or GD18 (terminated after 24 h). Lactating rats were injected on postnatal day 8 and terminated after 24 h, 3 or 11 days. The distribution of radioactivity in pregnant dams was influenced by both the state of pregnancy and time of termination after exposure. The percentage of recovered radioactivity in pregnant and lactating rats was highest in the liver and lungs. Radioactivity was quantitated in over 20 tissues. Radioactivity was found in the placenta and in fetuses of pregnant dams, and in the milk of lactating rats and in pups. Elimination of radioactivity was < 2% in urine and feces at each time point. Radioactivity remained in blood circulation up to 11 days after [(14) C(U)]C60 exposure. Biomarkers of inflammation, cardiovascular injury and oxidative stress were measured to study the biological impacts of [(14) C(U)]C60 exposure. Oxidative stress was elevated in female pups of exposed dams. Metabolomics analysis of urine showed that [(14) C(U)]C60 exposure to pregnant rats impacted the pathways of vitamin B, regulation of lipid and sugar metabolism and aminoacyl-tRNA biosynthesis. This study demonstrated that [(14) C(U)]C60 crosses the placenta at all stages of pregnancy examined, and is transferred to pups via milk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.