Evidence map›Paper›PMID 26081486›Full record

Trial reportEuropean journal of clinical nutrition2015

Consumption of sucrose-sweetened soft drinks increases plasma levels of uric acid in overweight and obese subjects: a 6-month randomised controlled trial.

J M Bruun, M Maersk, A Belza, A Astrup, B Richelsen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00777647 (Effect of Carbonated Soft Drinks on Body Weight, Fat Distribution and Metabolic Risk Factors), which is not on this map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00777647 nacompletednot on this map

Effect of Carbonated Soft Drinks on Body Weight, Fat Distribution and Metabolic Risk Factors

TypeinterventionalSponsorAarhus University HospitalRan2008 to 2010Enrolled60ConditionsObesity, Metabolic, Complications, Dietary HabitsArmsSugar-sweetened soft drink, Aspartame-sweetened soft drink, Semi-skimmed milk, Water
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J M Bruun1] Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Aarhus, Denmark [2] Medical Department, Regional Hospital of Randers, Randers, Denmark.
M MaerskDepartment of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Aarhus, Denmark.
A BelzaDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
A AstrupDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
B RichelsenDepartment of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital, Aarhus, Denmark.
Aarhus University Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSucrose-sweetened soft drinks (SSSDs) are associated with the development of metabolic disorders. Fructose is a major component of SSSDs and is demonstrated to induce uric acid (UA) production and stimulate fat accumulation independent of excess caloric intake. UA induce insulin resistance and low-grade inflammation, suggesting that UA may have a causal role in the development of metabolic complications. The objective of this study is to investigate the long-term effects of consuming SSSDs on circulating levels of UA in overweight and obese subjects. SUBJECTS/

methodsUsing a previously published study, circulating UA levels were assessed at baseline and after 6 months using chromogenic enzymatic absorptiometry. The study included 47 overweight and obese subjects without diabetes, randomised to consume 1 l daily of either SSSD (regular cola), isocaloric semi-skimmed milk, diet cola or water for 6 months.

resultsCirculating UA levels increased ~15% (P = 0.02) after the 6-month intervention in the SSSD group with no change in the other groups. In the SSSD group, circulating UA levels increased significantly after the intervention in both absolute (P = 0.005) and relative values (P = 0.004). The change in UA after the intervention correlated with changes in liver fat (P = 0.005), triglycerides (P = 0.02) and insulin (P = 0.002).

conclusionsIn this secondary analysis daily intake of 1 l SSSD for 6 months was found to increase circulating UA levels compared with isocaloric milk, diet cola and water. Thus, a high daily intake of SSSDs in overweight and obese subjects without overt diabetes may increase the risk of developing metabolic complications through the elevation of UA. This trial is registered at ClinicalTrials.gov as NCT00777647.

Indexed as

AdultAnimalsCarbonated BeveragesDietary SucroseDrinking WaterFemaleHumansInsulinLiverMaleMetabolic DiseasesMiddle AgedMilkObesityOverweightRisk FactorsDietary SucroseDrinking WaterInsulinSweetening AgentsTriglyceridesUric Acid

Identifiers

PMID26081486
OpenAlexW1547024874

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.