Evidence map›Paper›PMID 26081485›Full record

Trial reportEuropean journal of clinical nutrition2016

Double-blind, placebo-controlled pilot trial of L-Leucine-enriched amino-acid mixtures on body composition and physical performance in men and women aged 65-75 years.

T Ispoglou, H White, T Preston, S McElhone, J McKenna, K Hind

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400316 (Preventing Muscle Wasting During Rheumatoid Arthritis Flares), which is not on this map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06400316 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial

TypeinterventionalSponsorLeeds Beckett UniversityRan2024 to 2024Enrolled40ConditionsRheumatoid Arthritis, Muscle AtrophyArmsAmino Acid Supplement
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

T IspoglouCarnegie Faculty, School of Sport, Leeds Beckett University, Leeds, UK.
H WhiteCarnegie Faculty, School of Sport, Leeds Beckett University, Leeds, UK.
T PrestonScottish Universities Environmental Research Centre, University of Glasgow, Glasgow, Scotland.
S McElhone
J McKennaCarnegie Faculty, School of Sport, Leeds Beckett University, Leeds, UK.
K HindCarnegie Faculty, School of Sport, Leeds Beckett University, Leeds, UK.
Leeds Beckett University · GBScottish Universities Environmental Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAdequate protein intake is essential to retaining muscle and maintaining physical function, especially in the elderly, and L-Leucine has received attention as an essential amino acid (EAA) that enhances protein retention. The study's aim was to compare the efficacy of EAA mixtures on lean tissue mass (LTM) and functional performance (FP) in a healthy elderly population. SUBJECTS/

methodsThirty-six subjects (65-75 years) volunteered to receive capsules with EAAs (Groups A and B containing 20% and 40% L-Leucine, respectively) or placebo (lactose containing 0% L-Leucine, Group C) for 12 weeks. The daily amount ranged from 11 to 21 g (0.21 g/ kg/day) and was taken in two equal dosages alongside food, morning and evening. Main outcomes measured before and after intervention were LTM and FP (30-s arm-curl test; 30-s chair-stand test (30-CST); 6-min walk test (6-WT); and handgrip strength). Secondary outcomes included dietary intakes and physical activity.

resultsTwenty-five subjects (11 male and 14 female) completed the study (Group A, n=8; Group B, n=8; Group C, n=9). Gains associated with medium effect sizes were noted in LTM (Group B, 1.1 ±1.1%, P=0.003) and FP (Group A in 30-CST (11.0±11.5%, P=0.02) and 6-WT (8.8±10.0%, P=0.02); Group B in 6-WT (5.8±6.6%, P=0.03) and a trend in 30-CST (13.2±16.0, P=0.06)). Significant differences between groups were not observed in secondary outcomes.

conclusionsTwice-daily supplementation of EAAs containing 20% or 40% L-Leucine improved aspects of functional status and at the higher level improved LTM. Further work to establish change in a larger sample and palatable supplemental format is now required.

Indexed as

Dietary SupplementsAgedBody CompositionDietary ProteinsDouble-Blind MethodExercise TestFemaleHand StrengthHealthy VolunteersHumansLeucineMaleMotor ActivityMuscle, SkeletalMuscle StrengthPilot ProjectsDietary ProteinsLeucine

Identifiers

PMID26081485
PMCPMC4744242
OpenAlexW1803331912

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.