Evidence map›Paper›PMID 26081452›Full record

SynthesisNutrition reviews2015

Nut consumption and risk of cancer and type 2 diabetes: a systematic review and meta-analysis.

Lang Wu, Zhen Wang, Jingjing Zhu, Angela L Murad, Larry J Prokop, Mohammad H Murad

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 15 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 15 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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  4. Diets, Dietary Patterns, Single Foods and Pancreatic Cancer Risk: An Umbrella Review of Meta-Analyses.International journal of environmental research and public health · 2022
    Pooled it
  5. Effects of Hazelnut Consumption on Cardiometabolic Risk Factors and Acceptance: A Systematic Review.International journal of environmental research and public health · 2022
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  10. Effects of metformin on survival outcomes of lung cancer patients with type 2 diabetes mellitus: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016
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  13. Efficacy of Ligustrazine Injection as Adjunctive Therapy for Angina Pectoris: A Systematic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  14. Cyclooxygenase-2-1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls.Medical science monitor : international medical journal of experimental and clinical research · 2015
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lang WuL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA. Wu.Lang@mayo.edu.
Zhen WangL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Jingjing ZhuL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Angela L MuradL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Larry J ProkopL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mohammad H MuradL. Wu is with the Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang is with the Division of Health Care Policy and Research, Mayo Clinic, Rochester, Minnesota, USA. Z. Wang and M.H. Murad are with the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota, USA. J. Zhu is with the Program of Quantitative Methods in Education, University of Minnesota, Minneapolis, Minnesota, USA. A.L. Murad is with the Dan Abraham Healthy Living Center, Mayo Clinic, Rochester, Minnesota, USA. L.J. Prokop is with the Mayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota. M.H. Murad is with the Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Mayo Clinic in Arizona · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

contextThe identification of foods that can decrease the risk of cancer and type 2 diabetes may be helpful in reducing the burden of these diseases. Although nut consumption has been suggested to have a disease-preventive role, current evidence remains inconsistent.

objectiveThe aim of this systematic review and meta-analysis was to clarify the association between nut consumption and risk of cancer or type 2 diabetes. DATA SOURCES: Six databases were searched for relevant studies from the time of database inception to August 2014. Reference lists of relevant review articles were hand searched, and authors were contacted when data were insufficient. STUDY SELECTION: Eligible studies included epidemiological studies (case-control and cohort) or clinical trials that reported an association between nut consumption and the outcome of type 2 diabetes or specific cancers. DATA EXTRACTION: Two investigators independently extracted descriptive, quality, and risk data from included studies. DATA SYNTHESIS: Random-effects meta-analysis was used to pool relative risks from the included studies. The I(2) statistic was used to assess heterogeneity. A total of 36 eligible observational studies, which included 30,708 patients, were identified. The studies had fair methodological quality, and length of follow-up ranged between 4.6 years and 30 years. Comparison of the highest category of nut consumption with the lowest category revealed significant associations between nut consumption and decreased risk of colorectal cancer (3 studies each with separate estimates for males and females, RR 0.76, 95% confidence interval [95%CI] 0.61-0.96), endometrial cancer (2 studies, RR 0.58, 95%CI 0.43-0.79), and pancreatic cancer (1 study, RR 0.68, 95%CI 0.48-0.96). No significant association was found with other cancers or type 2 diabetes. Overall, nut consumption was significantly associated with a reduced risk of cancer incidence (RR 0.85, 95%CI 0.76-0.95).

conclusionsNut consumption may play a role in reducing cancer risk. Additional studies are needed to more accurately assess the relationship between nut consumption and the prevention of individual types of cancer, given the scarcity of available data.

Indexed as

DietNutsColorectal NeoplasmsDiabetes Mellitus, Type 2Endometrial NeoplasmsFemaleHumansIncidenceMaleNeoplasmsPancreatic NeoplasmsRisk Factorscancermeta-analysisnutsrisktype 2 diabetes.

Identifiers

PMID26081452
PMCPMC4560032
OpenAlexW2149354615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.