Evidence map›Paper›PMID 26081239›Full record

ArticleDiagnostic microbiology and infectious disease2015

In vitro immunomodulation for enhancing T cell-based diagnosis of Mycobacterium tuberculosis infection.

Madeline Slater, Minh-Chi Tran, Lauren Platt, Lien T Luu, Ha T Phan, Phuong T Pham, Tam B Do, Hanh T Nguyen, Rajiv L Gaur, Julie Parsonnet and 4 more

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Madeline SlaterDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Minh-Chi TranUniversity of California, San Francisco School of Medicine, San Francisco, CA, USA.
Lauren PlattClinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto, CA, USA.
Lien T LuuHanoi Lung Hospital, Hanoi, Vietnam.
Ha T PhanHanoi Lung Hospital, Hanoi, Vietnam.
Phuong T PhamHanoi Lung Hospital, Hanoi, Vietnam.
Tam B DoHanoi Lung Hospital, Hanoi, Vietnam.
Hanh T NguyenHanoi Lung Hospital, Hanoi, Vietnam.
Rajiv L GaurDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Julie ParsonnetDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Adithya CattamanchiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA.
Robert LuoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Payam NahidDivision of Pulmonary and Critical Care Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA, USA.
Niaz BanaeiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Clinical Microbiology Laboratory, Stanford University Medical Center, Palo Alto, CA, USA.
Stanford University · USHanoi Lung Hospital · VNUniversity of California, San Francisco · US

Funding

Global Epidemiology of Infectious DiseasesT32AI052073 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud, Stephen Patrick Luby · 2003 to 2026
$4.2M
NIAID NIH HHS T32 AI052073
6 · The paper itself

Abstract

Interferon-gamma release assays have limited sensitivity for detecting latent tuberculosis infection. In this study, we determine if the addition of immunomodulators to the QuantiFERON-TB Gold In-Tube (QFT-GIT) increased test sensitivity without compromising specificity. We prospectively compared QFT-GIT results with and without incubation with 2 immunomodulators (lipopolysaccharide [LPS] and polyinosine-polycytidylic acid [PolyIC]) in 2 cohorts-113 culture-confirmed tuberculosis (TB) subjects in Hanoi, Vietnam, and 226 documented QFT-GIT-negative, low TB risk health care workers undergoing annual TB screening at a US academic institution. Sensitivity of the tests in TB subjects was 84.1% with the standard QFT-GIT and 85.8% and 74.3% after incubation with LPS and PolyIC, respectively. Specificity in low TB risk health care workers was 100% with the standard QFT-GIT by design and 86.7% with LPS and 63.3% with PolyIC. In conclusion, use of the 2 immunomodulators did not improve sensitivity of the QFT-GIT in TB patients and reduced specificity in low-risk health care workers.

Indexed as

AdultAgedFemaleHealth PersonnelHumansImmunologic FactorsInterferon-gamma Release TestsLipopolysaccharidesMaleMiddle AgedMycobacterium tuberculosisPoly I-CProspective StudiesSensitivity and SpecificityT-LymphocytesTuberculosisImmunologic FactorsLipopolysaccharidesPoly I-CInterferon gamma release assaysPathogen associated molecular patternsQuantiferonTuberculosis

Identifiers

PMID26081239
PMCPMC5480369
OpenAlexW1935340313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.