ReviewPediatric nephrology (Berlin, Germany)2016
Severe antenatally diagnosed renal disorders: background, prognosis and practical approach.
Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 42 citations in OpenAlex.
- Prenatal body fluid analysis in the evaluation of CAKUT.Pediatric nephrology (Berlin, Germany) · 2026Review
- Management of patients with posterior urethral valves "from the fetus to adolescence": French national diagnostic and care protocol (NDCP).Orphanet journal of rare diseases · 2025Article
- Article
- Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study.World journal of pediatrics : WJP · 2024Article
- Prenatal diagnosis and treatment for fetal angiotensin converting enzyme deficiency.Prenatal diagnosis · 2024Article
- Achievements, priorities and strategies in pediatric nephrology in Europe: need for unifying approaches or acceptance of differences?Frontiers in pediatrics · 2024Article
- Amniotic fluid content in children with kidney and urinary tract anomalies determines pre- and postnatal development.Pediatric nephrology (Berlin, Germany) · 2023Article
- Fetal renal cystic disease and post-natal follow up-a single center experience.Frontiers in pediatrics · 2023Article
- Definition, diagnosis and management of fetal lower urinary tract obstruction: consensus of the ERKNet CAKUT-Obstructive Uropathy Work Group.Nature reviews. Urology · 2022Review
- Early clinical management of autosomal recessive polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Prenatal diagnosis of congenital megalourethra with imperforate anus.BMC pediatrics · 2019Review
- A clinical predictive model of chronic kidney disease in children with posterior urethral valves.Pediatric nephrology (Berlin, Germany) · 2019Article
- Causes of renal oligohydramnios: impact on prenatal counseling and postnatal outcome.Pediatric nephrology (Berlin, Germany) · 2018Article
- Prenatal parental decision-making and postnatal outcome in renal oligohydramnios.Pediatric nephrology (Berlin, Germany) · 2018Article
- Association between cord blood cystatin C levels and early mortality of neonates with congenital abnormalities of the kidney and urinary tract: a single-center, retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2017Article
- Disorders of fatty acid oxidation and autosomal recessive polycystic kidney disease-different clinical entities and comparable perinatal renal abnormalities.Pediatric nephrology (Berlin, Germany) · 2017Article
- Why do we need more data on MR volumetric measurements of the fetal lung?Pediatric radiology · 2016Review
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Nowadays most renal disorders, especially urinary tract malformations and renal cystic disease, are diagnosed antenatally. In cases of severe bilateral disease, intrauterine renal dysfunction may lead to renal oligohydramnios (ROH), resulting in pulmonary hypoplasia which affects perinatal mortality and morbidity as well as the long-term outcome. However, some infants may only have mild pulmonary and renal disease, and advances in postnatal and dialysis treatment have resulted in improved short- and long-term outcome even in those infants with severe ROH. Here, we review the current state of knowledge and clinical experience of patients presenting antenatally with severe bilateral renal disorders and ROH. By addressing underlying mechanisms, intrauterine tools of diagnosis and treatment as well as published outcome data, we hope to improve antenatal counselling and postnatal care. KEY SUMMARY POINTS: 1. Nowadays most renal disorders are diagnosed antenatally, especially urinary tract malformations and renal cystic disease. 2. Severe kidney dysfunction may lead to renal oligohydramnios, which can cause pulmonary hypoplasia and is a risk factor of perinatal mortality and postnatal renal outcome. However, as considerable clinical heterogeneity is present, outcome predictions need to be treated with caution. 3. Advances in postnatal and dialysis treatment have resulted in improved short- and long-term outcomes even in infants with severe renal oligohydramnios. 4. A multidisciplinary approach with specialist input is required when counselling a family with an ROH-affected fetus as the decision-making process is very challenging.
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