Evidence map›Paper›PMID 26081117›Full record

ReviewExperimental & applied acarology2016

Neoehrlichiosis: an emerging tick-borne zoonosis caused by Candidatus Neoehrlichia mikurensis.

Cornelia Silaghi, Relja Beck, José A Oteo, Martin Pfeffer, Hein Sprong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Experimental & applied acarology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 124 citations in OpenAlex.

  1. Review
  2. Article
  3. Molecular detection of vector-borne and hemotropic pathogens in raccoons (International journal for parasitology. Parasites and wildlife · 2026
    Review
  4. Article
  5. Article
  6. Molecular detection and characterization ofInternational journal for parasitology. Parasites and wildlife · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Ticks From Mink and Their Associated Microorganisms in Spain.Transboundary and emerging diseases · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Tick-Borne Bacterial Diseases in Europe: Threats to public health.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Review
  17. Article
  18. Article
  19. Spatial and temporal variation of five different pathogens and symbionts inCurrent research in parasitology & vector-borne diseases · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 5 countries.

Cornelia SilaghiNational Center for Vector Entomology, Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 266a, 8057, Zurich, Switzerland. cornelia.silaghi@uzh.ch.
Relja BeckDepartment for Bacteriology and Parasitology, Croatian Veterinary Institute, Zagreb, Croatia.
José A OteoCenter of Rickettsiosis and Arthropod-borne Diseases, Hospital San Pedro-Center of Biomedical Research of La Rioja, Logroño, Spain.
Martin PfefferInstitute for Animal Hygiene and Veterinary Public Health, University of Leipzig, Leipzig, Germany.
Hein SprongLaboratory for Zoonoses and Environmental Microbiology, National Institute of Public Health and Environment (RIVM), Bilthoven, The Netherlands.
Croatian Veterinary Institute · HRHospital San Pedro · ESLeipzig University · DENational Institute for Public Health and the Environment · NLUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candidatus Neoehrlichia mikurensis is an emerging tick-borne pathogen causing a systemic inflammatory syndrome mostly in persons with underlying hematologic or autoimmune diseases. As it is neither well-known nor well-recognized, it might be misdiagnosed as recurrence of the underlying disease or as an unrelated arteriosclerotic vascular event. The pathogen is transmitted by hard ticks of the genus Ixodes and is closely associated with rodents in which transplacental transmission occurs. Transovarial transmission in ticks has not yet been shown. Infection rates vary greatly in ticks and rodents, but the causes for its spatiotemporal variations are largely unknown. This review summarizes the current state of knowledge on the geographical distribution and clinical importance of Ca. N. mikurensis. By elucidating the life history traits of this pathogen and determining more accurately its incidence in the human population, a better assessment of its public health relevance can be made. Most urgent research needs are the in vitro-cultivation of the pathogen, the development of specific serological tests, the determination of the full genomic sequence, the routine implementation of molecular diagnosis in diseased patients with a particular panel of underlying diseases, and promoting the knowledge about neoehrlichiosis among general practitioners, hospital physicians and the risk groups such as forest workers or immune-compromised people to raise awareness about this disease that can easily be treated when correctly diagnosed.

Indexed as

AnaplasmataceaeAnaplasmataceae InfectionsAnimalsCommunicable Diseases, EmergingHumansIxodesTick-Borne DiseasesZoonosesAnaplasmataceaeApodemus spp.Candidatus Neoehrlichia mikurenisDiagnosticsHaematological disordersImmunodeficiencyIxodes persulcatusIxodes ricinusMyodes spp.RodentsThrombosisTreatment

Identifiers

PMID26081117
OpenAlexW2433699676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.