ArticleAging2015
Interstitial pericytes decrease in aged mouse kidneys.
Article in Aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Pericytes in tissue fibrosis.American journal of physiology. Cell physiology · 2025Review
- A high-resolution view of the heterogeneous aging endothelium.Angiogenesis · 2024Review
- Phosphodiesterase inhibitor ameliorates senescent changes of renal interstitial pericytes in aging kidney.Aging cell · 2024Article
- The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities.Journal of ovarian research · 2023Review
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury.Nature reviews. Nephrology · 2022Review
- Pressure-Natriuresis Response Is Diminished in Old Age.Frontiers in cardiovascular medicine · 2022Article
- Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach.Translational psychiatry · 2021Article
- Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature.Stem cells translational medicine · 2021Article
- Pericyte migration and proliferation are tightly synchronized to endothelial cell sprouting dynamics.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Global transcriptomic changes occur in aged mouse podocytes.Kidney international · 2020Article
- Red Carrot Cells CulturedFrontiers in bioengineering and biotechnology · 2020Article
- The pericyte microenvironment during vascular development.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss.Nature neuroscience · 2019Article
- Serum Stem Cell Factor Level Predicts Decline in Kidney Function in Healthy Aging Adults.The journal of nutrition, health & aging · 2019Article
- Microvascular bioengineering: a focus on pericytes.Journal of biological engineering · 2019Review
- Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.Nature reviews. Cardiology · 2018Review
- Pericytes in the renal vasculature: roles in health and disease.Nature reviews. Nephrology · 2018Review
- Mechanisms of altered renal sodium handling in age-related hypertension.American journal of physiology. Renal physiology · 2018Review
- Establishment and characterization of an embryonic pericyte cell line.Microcirculation (New York, N.Y. : 1994) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
With increasing age, the kidney undergoes characteristic changes in the glomerular and tubulo-interstitial compartments, which are ultimately accompanied by reduced kidney function. Studies have shown age-related loss of peritubular vessels. Normal peritubular vessel tone, function and survival depend on neighboring pericytes. Pericyte detachment leads to vascular damage, which can be accompanied by their differentiation to fibroblasts and myofibroblasts, a state that favors matrix production. To better understand the fate of pericytes in the aged kidney, 27 month-old mice were studied. Compared to 3 month-old young adult mice, aged kidneys showed a substantial decrease in capillaries, identified by CD31 staining, in both cortex and medulla. This was accompanied by a marked decrease in surrounding NG2+ / PDGFRβ+ pericytes. This decrease was more pronounced in the medulla. Capillaries devoid of pericytes were typically dilated in aged mice. Aged kidneys were also characterized by interstitial fibrosis due to increased collagen-I and -III staining. This was accompanied by an increase in the number of pericytes that acquired a pro-fibrotic phenotype, identified by increased PDGFRβ+ / αSMA+ staining. These findings are consistent with the decline in kidney interstitial pericytes as a critical step in the development of changes to the peritubular vasculature with aging, and accompanying fibrosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.