Evidence map›Paper›PMID 26080804›Full record

Trial reportNutrition journal2015

Effect of almond consumption on vascular function in patients with coronary artery disease: a randomized, controlled, cross-over trial.

C-Y Oliver Chen, Monika Holbrook, Mai-Ann Duess, Mustali M Dohadwala, Naomi M Hamburg, Bela F Asztalos, Paul E Milbury, Jeffrey B Blumberg, Joseph A Vita

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00782015 (Effects of Almonds on Vascular Reactivity and Biomarkers of Inflammation, Oxidative Stress and Endothelial Function in Patients With Coronary Artery Disease), which is not on this map. Cited by 43 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00782015 nacompletednot on this map

Effects of Almonds on Vascular Reactivity and Biomarkers of Inflammation, Oxidative Stress and Endothelial Function in Patients With Coronary Artery Disease

TypeinterventionalSponsorTufts UniversityRan2008 to 2011Enrolled45ConditionsVascular Disease, Endothelial Dysfunction, Heart Disease, Cardiovascular DiseasesArmsAlmonds, Placebo Comparator:
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

C-Y Oliver ChenJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. oliver.chen@tufts.edu.
Monika HolbrookEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA. moholbro@bu.edu.
Mai-Ann DuessEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA. mduess@bu.edu.
Mustali M DohadwalaEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA. mustali.dohadwala@gmail.com.
Naomi M HamburgEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA. nhamburg@bu.edu.
Bela F AsztalosJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. bela.asztalos@tufts.edu.
Paul E MilburyJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. pual.milbury@tufts.edu.
Jeffrey B BlumbergJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. jeffrey.blumberg@tufts.edu.
Joseph A VitaEvans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlmonds reduce cardiovascular disease risk via cholesterol reduction, anti-inflammation, glucoregulation, and antioxidation. The objective of this randomized, controlled, cross-over trial was to determine whether the addition of 85 g almonds daily to a National Cholesterol Education Program (NCEP) Step 1 diet (ALM) for 6 weeks would improve vascular function and inflammation in patients with coronary artery disease (CAD). RESEARCH DESIGN AND

methodsA randomized, controlled, crossover trial was conducted in Boston, MA to test whether as compared to a control NCEP Step 1 diet absent nuts (CON), incorporation of almonds (85 g/day) into the CON diet (ALM) would improve vascular function and inflammation. The study duration was 22 weeks including a 6-weeks run-in period, two 6-weeks intervention phases, and a 4-weeks washout period between the intervention phases. A total of 45 CAD patients (27 F/18 M, 45-77 y, BMI = 20-41 kg/m(2)) completed the study. Drug therapies used by patients were stable throughout the duration of the trial.

resultsThe addition of almonds to the CON diet increased plasma α-tocopherol status by a mean of 5.8%, reflecting patient compliance (P ≤0.05). However, the ALM diet did not alter vascular function assessed by measures of flow-mediated dilation, peripheral arterial tonometry, and pulse wave velocity. Further, the ALM diet did not significantly modify the serum lipid profile, blood pressure, C-reactive protein, tumor necrosis factor-α or E-selectin. The ALM diet tended to decrease vascular cell adhesion molecule-1 by 5.3% (P = 0.064) and increase urinary nitric oxide by 17.5% (P = 0.112). The ALM intervention improved the overall quality of the diet by increasing calcium, magnesium, choline, and fiber intakes above the Estimated Average Requirement (EAR) or Recommended Dietary Allowance (RDA).

conclusionsThus, the addition of almonds to a NECP Step 1 diet did not significantly impact vascular function, lipid profile or systematic inflammation in CAD patients receiving good medical care and polypharmacy therapies but did improve diet quality without any untoward effect.

trial registrationThe trial was registered with the ClinicalTrials.Gov with the identifier: NCT00782015.

Indexed as

Prunus dulcisAdultAgedAged, 80 and overalpha-TocopherolBiomarkersBostonCholesterol, HDLCholesterol, LDLCoronary Artery DiseaseC-Reactive ProteinCross-Over StudiesEnergy IntakeE-SelectinFemaleFood Qualityalpha-TocopherolBiomarkersCholesterol, HDLCholesterol, LDLC-Reactive ProteinE-SelectinIL6 protein, humanInterleukin-6Nitric OxideSELE protein, humanTriglyceridesTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID26080804
PMCPMC4469426

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.